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The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening

Franasiak, Jason M., M.D ; Forman, Eric J., M.D ; Hong, Kathleen H., M.D ; Werner, Marie D., M.D ; Upham, Kathleen M., B.S ; Treff, Nathan R., Ph.D ; Scott, Richard T., M.D

Fertility and sterility, 2014-03, Vol.101 (3), p.656-663.e1 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening
Autor: Franasiak, Jason M., M.D ; Forman, Eric J., M.D ; Hong, Kathleen H., M.D ; Werner, Marie D., M.D ; Upham, Kathleen M., B.S ; Treff, Nathan R., Ph.D ; Scott, Richard T., M.D
Assuntos: Adult ; Aneuploidy ; Biopsy - methods ; Blastocyst - pathology ; Blastocyst - physiology ; Cohort Studies ; Comprehensive chromosomal screening ; Ectoderm - pathology ; Ectoderm - physiology ; embryonic aneuploidy ; Female ; Genetic Testing - methods ; Humans ; Internal Medicine ; IVF ; Maternal Age ; Middle Aged ; Obstetrics and Gynecology ; preimplantation genetic screening ; Retrospective Studies ; trophectoderm biopsy ; Young Adult
É parte de: Fertility and sterility, 2014-03, Vol.101 (3), p.656-663.e1
Notas: ObjectType-Case Study-3
SourceType-Scholarly Journals-1
content type line 23
ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
Descrição: Objective To determine the relationship between the age of the female partner and the prevalence and nature of human embryonic aneuploidy. Design Retrospective. Setting Academic. Patient(s) Trophectoderm biopsies. Intervention(s) Comprehensive chromosomal screening performed on patients with blastocysts available for biopsy. Main Outcome Measure(s) Evaluation of the impact of maternal age on the prevalence of aneuploidy, the probability of having no euploid embryos within a cohort, the complexity of aneuploidy as gauged by the number of aneuploid chromosomes, and the trisomy/monosomy ratio. Result(s) Aneuploidy increased predictably after 26 years of age. A slightly increased prevalence was noted at younger ages, with >40% aneuploidy in women 23 years and under. The no euploid embryo rate was lowest (2% to 6%) in women aged 26 to 37, was 33% at age 42, and was 53% at age 44. Among the biopsies with aneuploidy, 64% involved a single chromosome, 20% two chromosomes, and 16% three chromosomes, with the proportion of more complex aneuploidy increasing with age. Finally, the trisomy/monosomy ratio approximated 1 and increased minimally with age. Conclusion(s) The lowest risk for embryonic aneuploidy was between ages 26 and 30. Both younger and older age groups had higher rates of aneuploidy and an increased risk for more complex aneuploidies. The overall risk did not measurably change after age 43. Trisomies and monosomies are equally prevalent.
Editor: United States: Elsevier Inc
Idioma: Inglês

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The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening

Franasiak, Jason M., M.D ; Forman, Eric J., M.D ; Hong, Kathleen H., M.D ; Werner, Marie D., M.D ; Upham, Kathleen M., B.S ; Treff, Nathan R., Ph.D ; Scott, Richard T., M.D

United States: Elsevier Inc

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