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Levodopa may improve orthostatic tremor: case report and trial of treatment

Wills, A J ; Brusa, L ; Wang, H C ; Brown, P ; Marsden, C D

Journal of neurology, neurosurgery and psychiatry, 1999-05, Vol.66 (5), p.681-684 [Peer Reviewed Journal]

London: BMJ Publishing Group Ltd

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Title:
Levodopa may improve orthostatic tremor: case report and trial of treatment
Author: Wills, A J ; Brusa, L ; Wang, H C ; Brown, P ; Marsden, C D
Subjects: Aged ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Confidence intervals ; Electromyography ; Female ; Humans ; idiopathic Parkinson’s disease ; levodopa ; Levodopa - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Muscles - physiopathology ; Neuropharmacology ; orthostatic tremor ; Parkinson's disease ; Patients ; Pharmacology. Drug treatments ; Posture - physiology ; Short Report ; Tremor - drug therapy ; Tremor - physiopathology ; Walking
Is Part Of: Journal of neurology, neurosurgery and psychiatry, 1999-05, Vol.66 (5), p.681-684
Notes: istex:B0430C445CAEF7DB9546C167E803A81C462CD138
Dr A J Wills, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. Telephone 0044 171 837 3611; fax 0044 171 263 1641.
ark:/67375/NVC-CS4V7J4Q-4
PMID:10209189
local:jnnp;66/5/681
href:jnnp-66-681.pdf
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Report-3
ObjectType-Case Study-4
Description: Primary orthostatic tremor is a regular fast lower limb tremor causing unsteadiness on standing. Treatment is generally unsatisfactory. A patient with primary orthostatic tremor who 9 years later developed levodopa responsive idiopathic Parkinson’s disease is described. The patient exhibited the classic features of primary orthostatic tremor with relief of the tremor by walking or sitting while treated with levodopa. However, in the “off” state, when the benefits of levodopa disappeared, this orthostatic tremor was continuous and severely compromised the patient’s gait. On the basis of this finding eight patients with primary orthostatic tremor were treated with levodopa. Five patients experienced benefit and elected to remain on long term treatment. This study is the first trial of therapy in primary orthostatic tremor and suggests that levodopa can lead to good symptomatic relief in this potentially disabling condition.
Publisher: London: BMJ Publishing Group Ltd
Language: English

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Levodopa may improve orthostatic tremor: case report and trial of treatment

Wills, A J ; Brusa, L ; Wang, H C ; Brown, P ; Marsden, C D

London: BMJ Publishing Group Ltd

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