Idioma:

Transmission of Streptococcus pneumoniae in an urban slum community

Reis, Joice Neves ; Palma, Tania ; Ribeiro, Guilherme S ; Pinheiro, Ricardo M ; Ribeiro, Cassio Tâmara ; Cordeiro, Soraia Machado ; da Silva Filho, H.P ; Moschioni, Monica ; Thompson, Terry A ; Spratt, Brian ; Riley, Lee W ; Barocchi, Michele A ; Reis, Mitermayer G ; Ko, Albert I

The Journal of infection, 2008-09, Vol.57 (3), p.204-213 [Periódico revisado por pares]

Kidlington: Elsevier Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Transmission of Streptococcus pneumoniae in an urban slum community
Autor: Reis, Joice Neves ; Palma, Tania ; Ribeiro, Guilherme S ; Pinheiro, Ricardo M ; Ribeiro, Cassio Tâmara ; Cordeiro, Soraia Machado ; da Silva Filho, H.P ; Moschioni, Monica ; Thompson, Terry A ; Spratt, Brian ; Riley, Lee W ; Barocchi, Michele A ; Reis, Mitermayer G ; Ko, Albert I
Assuntos: Adolescent ; Adult ; Age Factors ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Bacterial diseases ; Bacterial Typing Techniques ; Biological and medical sciences ; Brazil - epidemiology ; Carrier State - epidemiology ; Carrier State - microbiology ; Carrier State - transmission ; Child ; Child, Preschool ; Cluster Analysis ; DNA Fingerprinting ; DNA, Bacterial - genetics ; Drug Resistance, Bacterial ; Female ; General aspects ; Genotype ; Heptavalent Pneumococcal Conjugate Vaccine ; Human bacterial diseases ; Humans ; Infant ; Infectious Disease ; Infectious diseases ; Male ; Medical sciences ; Meningococcal Vaccines - immunology ; Microbial Sensitivity Tests ; Nasopharyngeal carriage ; Pneumococcal conjugate vaccines ; Pneumococcal Vaccines - immunology ; Poverty Areas ; Risk Factors ; Schools ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - classification ; Streptococcus pneumoniae - isolation & purification ; Urban slums
É parte de: The Journal of infection, 2008-09, Vol.57 (3), p.204-213
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Conflict of interest: The authors do not have any commercial or other association that might pose a conflict of interest with respect to the study, except for M.M. and M.A.B who are employees of Novartis Vaccines.
Descrição: Summary Background Inhabitants of slum settlements represent a significant proportion of the population at risk for pneumococcal disease in developing countries. Methods We conducted a household survey of pneumococcal carriage among residents of a slum community in the city of Salvador, Brazil. Results Among 262 subjects, 95 (36%) were colonized with Streptococcus pneumoniae . Children <5 years of age (OR, 8.0; 95% CI, 3.5–18.6) and those who attended schools (OR, 2.7, 95% CI, 1.2–6.0) had significantly higher risk of being colonized. Of 94 isolates obtained from colonized individuals, 51% had serotypes included in the seven-valent pneumococcal conjugate vaccine. Overall, 10% (9 of 94 isolates) were nonsusceptible to penicillin and 28% (27 of 94 isolates) were resistant to cotrimoxazole. BOX-PCR, PFGE and MLST analyses found that 44% of the carriage isolates belonged to 14 distinct clonal groups. Strains of the same clonal group were isolated from multiple members of 9 out of the 39 study households. Nineteen carriage isolates had genotypes that were the same as those identified among 362 strains obtained from active surveillance for meningitis. Conclusions The study's findings indicate that there is significant intra- and inter-household spread of S. pneumoniae in the slum community setting. However, a limited number of clones encountered during carriage among slum residents were found to cause invasive disease.
Editor: Kidlington: Elsevier Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Transmission of Streptococcus pneumoniae in an urban slum community

Reis, Joice Neves ; Palma, Tania ; Ribeiro, Guilherme S ; Pinheiro, Ricardo M ; Ribeiro, Cassio Tâmara ; Cordeiro, Soraia Machado ; da Silva Filho, H.P ; Moschioni, Monica ; Thompson, Terry A ; Spratt, Brian ; Riley, Lee W ; Barocchi, Michele A ; Reis, Mitermayer G ; Ko, Albert I

Kidlington: Elsevier Ltd

Buscando em bases de dados remotas. Favor aguardar.