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Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France

Weber, P. ; Filipecki, J. ; Bingen, E. ; Fitoussi, F. ; Goldfarb, G. ; Chauvin, J. P. ; Reitz, C. ; Portier, H.

Journal of antimicrobial chemotherapy, 2001-08, Vol.48 (2), p.291-294 [Periódico revisado por pares]

Oxford: Oxford University Press

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Título:
Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France
Autor: Weber, P. ; Filipecki, J. ; Bingen, E. ; Fitoussi, F. ; Goldfarb, G. ; Chauvin, J. P. ; Reitz, C. ; Portier, H.
Assuntos: Adenoids - drug effects ; Adenoids - microbiology ; Adolescent ; Adult ; Anti-Bacterial Agents - pharmacology ; Anti-Bacterial Agents - therapeutic use ; Bacteriology ; Biological and medical sciences ; Child ; Drug Resistance, Bacterial - genetics ; ermB gene ; ermTR gene ; France ; Fundamental and applied biological sciences. Psychology ; Genetics ; Humans ; Macrolides ; mefA gene ; Microbiology ; Phenotype ; Streptococcal Infections - drug therapy ; Streptococcal Infections - genetics ; Streptococcal Infections - microbiology ; Streptococcus ; Streptococcus pyogenes - drug effects ; Streptococcus pyogenes - genetics ; Streptococcus pyogenes - isolation & purification ; Tonsillitis - drug therapy ; Tonsillitis - genetics ; Tonsillitis - microbiology
É parte de: Journal of antimicrobial chemotherapy, 2001-08, Vol.48 (2), p.291-294
Notas: PII:1460-2091
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Descrição: Three hundred and three strains of group A streptococci (GAS) isolated from adults with pharyngitis were tested to evaluate their phenotype of resistance to macrolides–lincosamides and to search for macrolide resistance genes. MICs of clarithromycin were determined. The overall rate of resistance to both erythromycin and clarithromycin was 9.6%. Constitutive, inducible and M phenotypes of resistance were detected in 4.3, 2 and 3.3% of strains, respectively. All constitutive phenotypes harboured ermB genes, whereas inducible phenotypes had the ermTR gene and M phenotypes had the mefA gene. In France, the current resistance rate of GAS to erythromycin and clarithromycin remains low.
Editor: Oxford: Oxford University Press
Idioma: Inglês

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Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France

Weber, P. ; Filipecki, J. ; Bingen, E. ; Fitoussi, F. ; Goldfarb, G. ; Chauvin, J. P. ; Reitz, C. ; Portier, H.

Oxford: Oxford University Press

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