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Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin

Mori, R.C.T ; Hirabara, S.M ; Hirata, A.E ; Okamoto, M.M ; Machado, U.F

Diabetes, obesity & metabolism, 2008-07, Vol.10 (7), p.596-600

Oxford, UK: Oxford, UK : Blackwell Publishing Ltd

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  • Título:
    Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin
  • Autor: Mori, R.C.T ; Hirabara, S.M ; Hirata, A.E ; Okamoto, M.M ; Machado, U.F
  • Assuntos: Animals ; glimepiride ; Glucose Transporter Type 4 ; GLUT4 ; GSK3 ; Hypoglycemic Agents - pharmacology ; Insulin Resistance ; liver ; Liver - metabolism ; MSG ; Muscle, Skeletal - metabolism ; Rats ; Rats, Wistar ; skeletal muscle ; Sulfonylurea Compounds - pharmacology
  • É parte de: Diabetes, obesity & metabolism, 2008-07, Vol.10 (7), p.596-600
  • Notas: http://dx.doi.org/10.1111/j.1463-1326.2008.00870.x
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  • Descrição: Glimepiride, a low-potency insulin secretagogue, is as efficient on glycaemic control as other sulphonylureas, suggesting an additional insulin-sensitizer role. The aim of the present study was to confirm the insulin-sensitizer role of glimepiride and to show extra-pancreatic effects of the drug. Three-month-old monosodium glutamate (MSG)-induced obese insulin-resistant rats were treated (OG) or not treated (O) with glimepiride for 4 weeks and compared with age-matched non-obese rats (C). Insulin sensitivity in whole body, glucose transporter 4 (GLUT4) protein content, glucose uptake and glycogen synthesis in oxidative skeletal muscle and phospho-glycogen synthase kinase (p-GSK3) and glycogen content in liver were analysed. Insulin sensitivity, analysed by the insulin tolerance test, was 30% lower in O than in C rats (p < 0.05), and OG rats recovered this parameter (p < 0.05). In oxidative muscle, glimepiride increased the GLUT4 protein content (50%, p < 0.001) and recovered the obesity-induced reduction (~20%) of the in vitro insulin-stimulated glucose uptake and incorporation into glycogen. In liver, glimepiride increased p-GSK3 (p < 0.01) and glycogen (p < 0.05) contents. The increased GLUT4 protein expression and glucose utilization in oxidative muscle and the increased insulin sensitivity and glycogen storage in liver evidence the insulin-sensitizer effect of glimepiride, which must be important to enable the glimepiride drug to promote an efficient glycaemic control.
  • Editor: Oxford, UK: Oxford, UK : Blackwell Publishing Ltd
  • Idioma: Inglês
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