skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines

Karakaş, Nihal ; Okur, Mehmet Evren ; Öztunç, Nurşah ; Çiçek Polat, Derya ; Karadağ, Ayşe Esra

Turkish Journal of Biochemistry, 2021-01, Vol.46 (2), p.213-221 [Periódico revisado por pares]

De Gruyter

Texto completo disponível

Citações Citado por
  • Título:
    Laurocerasus officinalis Roem. fruit extract induces cell death through caspase mediated apoptosis in gastric cancer cell lines
  • Autor: Karakaş, Nihal ; Okur, Mehmet Evren ; Öztunç, Nurşah ; Çiçek Polat, Derya ; Karadağ, Ayşe Esra
  • Assuntos: antioksidan aktivite ; antioxidant activity ; apoptosis ; apoptoz ; gastric cancer ; mide kanseri ; Rosaceae
  • É parte de: Turkish Journal of Biochemistry, 2021-01, Vol.46 (2), p.213-221
  • Descrição: Abstract Objectives Laurocerasus officinalis Roem . fruits are traditionally used for several health problems. Although there are some studies about its antiproliferative effects on different cancer cells, no study was reported about its potential therapeutic efficacy against gastric cancers which is the most malignant disease in the digestive system with high morbidity and mortality. Methods This study was aimed to evaluate L. officinalis fruit extract phytochemical contents as well as to compare anticancer effects on gastric cancer cells. The antioxidant activities were determined by ABTS and DPPH assays. Anticancer effects were measured by cell viability assays, then apoptotic proteins were analyzed by western blotting and flow cytometry. Results Laurocerasus officinalis fruit methanol extract showed moderate antioxidant activity by ABTS • and DPPH • assays. Significant cytotoxic activities and caspase mediated apoptosis were detected in the extract treated MKN-45 and AGS gastric cancer cells respectively while sparing healthy cells. Conclusion Our results showed that the L. officinalis Roem. extract has significant anticancer efficacy on gastric cancer cell lines; therefore, it can be further studied to determine its potential therapeutic components.
  • Editor: De Gruyter
  • Idioma: Turco;Inglês
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.