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Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

Liu, Mingyong ; Chen, Keqiang ; Yoshimura, Teizo ; Liu, Ying ; Gong, Wanghua ; Wang, Aimin ; Gao, Ji-Liang ; Murphy, Philip M ; Wang, Ji Ming

Scientific reports, 2012-11, Vol.2, p.786 [Periódico revisado por pares]

England: Nature Publishing Group

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Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes
Autor: Liu, Mingyong ; Chen, Keqiang ; Yoshimura, Teizo ; Liu, Ying ; Gong, Wanghua ; Wang, Aimin ; Gao, Ji-Liang ; Murphy, Philip M ; Wang, Ji Ming
Assuntos: Animals ; Bacteria ; Cell adhesion & migration ; Cell Movement ; Chemokines - metabolism ; Chemotaxis ; HEK293 Cells ; Humans ; Hydrogen Peroxide - metabolism ; Immune response ; Infections ; Listeria ; Listeria monocytogenes ; Listeria monocytogenes - immunology ; Listeria monocytogenes - pathogenicity ; Listeriosis - microbiology ; Listeriosis - mortality ; Listeriosis - pathology ; Liver - metabolism ; Liver - microbiology ; Mice ; Mice, Knockout ; Neutrophil Infiltration ; Neutrophils ; Neutrophils - immunology ; Neutrophils - metabolism ; Pathogens ; Phagocytosis ; Receptors, Formyl Peptide - deficiency ; Receptors, Formyl Peptide - genetics ; Receptors, Formyl Peptide - metabolism ; Rodents
É parte de: Scientific reports, 2012-11, Vol.2, p.786
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Listeria monocytogenes (Listeria) causes opportunistic infection in immunocompromised hosts with high mortality. Resistance to Listeria depends on immune responses and recruitment of neutrophils of the immune system into infected sites is an early and critical step. Mouse neutrophils express two G protein-coupled formylpeptide receptor subtypes Fpr1 and Fpr2 that recognize bacterial and host-derived chemotactic molecules including Listeria peptides for cell migration and activation. Here we report deficiency in Fprs exacerbated the severity of the infection and increased the mortality of infected mice. The mechanism involved impaired early neutrophil recruitment to the liver with Fpr1 and Fpr2 being sole receptors for neutrophils to sense Listeria chemoattractant signals and for production of bactericidal superoxide. Thus, Fprs are essential sentinels to guide the first wave of neutrophil infiltration in the liver of Listeria-infected mice for effective elimination of the invading pathogen.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes

Liu, Mingyong ; Chen, Keqiang ; Yoshimura, Teizo ; Liu, Ying ; Gong, Wanghua ; Wang, Aimin ; Gao, Ji-Liang ; Murphy, Philip M ; Wang, Ji Ming

England: Nature Publishing Group

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