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Antinociceptive effect of hydantoin 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione in mice

de Queiroz, Ronaldo Bezerra ; de Carvalho, Fabíola Lélis ; Fonsêca, Diogo Vilar da ; Barbosa-Filho, José Maria ; Salgado, Paula Regina Rodrigues ; Paulo, Luciano Leite ; de Queiroz, Ana Bárbara Maroja ; Pordeus, Liana Clébia de Morais ; de Souza, Severino Araújo ; Souza, Helivaldo Diogenes da Silva ; Lira, Bruno Freitas ; de Athayde-Filho, Petrônio Filgueiras

Molecules (Basel, Switzerland), 2015-01, Vol.20 (1), p.974-986 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Antinociceptive effect of hydantoin 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione in mice
Autor: de Queiroz, Ronaldo Bezerra ; de Carvalho, Fabíola Lélis ; Fonsêca, Diogo Vilar da ; Barbosa-Filho, José Maria ; Salgado, Paula Regina Rodrigues ; Paulo, Luciano Leite ; de Queiroz, Ana Bárbara Maroja ; Pordeus, Liana Clébia de Morais ; de Souza, Severino Araújo ; Souza, Helivaldo Diogenes da Silva ; Lira, Bruno Freitas ; de Athayde-Filho, Petrônio Filgueiras
Assuntos: Acetic Acid ; Amino acids ; Analgesia ; Analgesics - pharmacology ; Animals ; anti-inflammatory ; antinociceptive ; Anxiety ; Behavior ; Behavior, Animal ; Derivatives ; Drug dosages ; Effectiveness ; Formaldehyde ; Hydantoin ; Hydantoins - chemistry ; Hydantoins - pharmacology ; Male ; Maze Learning - drug effects ; Mice ; Pain ; psychopharmacology ; Rotarod Performance Test ; Similarity ; Toxicity Tests, Acute
É parte de: Molecules (Basel, Switzerland), 2015-01, Vol.20 (1), p.974-986
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Imidazolidine derivatives, or hydantoins, are synthetic compounds with different therapeutic applications. Many imidazolidine derivatives have psychopharmacological properties, such as phenytoin, famous for its anticonvulsant efficacy, but also effective in the treatment of neuropathic pain. The hydantoin, 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione (IM-3), synthesized from the amino acid, glycine, was selected for psychopharmacological studies in mice on the basis of its chemical and structural similarity with phenytoin. The first step of this study was to define the LD50, which determined the doses of 50, 100 and 200 mg/kg for subsequent tests. The results obtained from the behavioral screening indicated that IM-3 produces decreased ambulation and analgesia in mice. Motor coordination and anxiety behavior were not affected by treatment with IM-3, as observed in the rotarod and elevated plus-maze tests, respectively. Regarding its antinociceptive properties, IM-3 showed efficacy in the acetic acid-induced writhing test by increasing the latency of the first writhe and reducing the number of writhes, as well as reducing the paw licking time in the second phase of the formalin test. The behavior of treated animals exposed to the hot plate test, however, did not differ from that of the control group. These data suggest that IM-3 has antinociceptive effects in mice, which is probably mediated by anti-inflammatory mechanisms.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Antinociceptive effect of hydantoin 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione in mice

Switzerland: MDPI AG

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