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15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model

Chen, Qiong-Hua ; Zhou, Wei-Dong ; Pu, De-Min ; Huang, Qian-Sheng ; Li, Tian ; Chen, Qing-Xi

Fertility and sterility, 2010-03, Vol.93 (5), p.1440-1447 [Periódico revisado por pares]

United States

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Título:
15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model
Autor: Chen, Qiong-Hua ; Zhou, Wei-Dong ; Pu, De-Min ; Huang, Qian-Sheng ; Li, Tian ; Chen, Qing-Xi
Assuntos: Animals ; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage ; Anti-Inflammatory Agents, Non-Steroidal - pharmacology ; Ascitic Fluid - cytology ; Ascitic Fluid - enzymology ; Disease Models, Animal ; Disease Progression ; Down-Regulation ; Endometriosis - drug therapy ; Endometriosis - enzymology ; Endometriosis - pathology ; Endometrium - drug effects ; Endometrium - enzymology ; Endometrium - pathology ; Endometrium - transplantation ; Enzyme-Linked Immunosorbent Assay ; Estrus ; Female ; Gene Expression Regulation, Enzymologic - drug effects ; Injections, Intraperitoneal ; Lipoxins - administration & dosage ; Lipoxins - pharmacology ; Matrix Metalloproteinase 2 - genetics ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase 9 - metabolism ; Mice ; Mice, Inbred BALB C ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - metabolism
É parte de: Fertility and sterility, 2010-03, Vol.93 (5), p.1440-1447
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: To examine the pro-resolution actions of 15-epi-lipoxin A(4) (LXA(4)) on endometriotic lesions, on the concentrations and activities of matrix metalloproteinases (MMP-2 and MMP-9) in murine endometriosis. Prospective, vehicle-controlled experimental study. Animal research facility. BALB/c mice. Endometriosis (EM) was induced in 30 mice. Fifteen of them were administered LXA(4) for 24 days (LXA(4) group), whereas the other 15 served as a control group (EM group). Another 15 sham-operated mice (sham-operated group) were treated with vehicles. The weight of the endometriotic lesions was measured. The concentrations, mRNA, and activities of MMP-2 and MMP-9 were determined by enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, and gelatin zymography, respectively. Compared with EM group, the weight of the endometriotic lesions was decreased, the concentrations of MMP-2 and MMP-9 dropped, the mRNA levels of MMP-2 and MMP-9 in the peritoneal fluid cells and the endometriotic lesions were reduced, and the activities of MMP-2 and MMP-9 were inhibited in the LXA(4) group. LXA(4) may inhibit the progression of endometriosis possibly by lowering the concentrations and the activities of MMP-2 and MMP-9.
Editor: United States
Idioma: Inglês

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15-Epi-lipoxin A(4) inhibits the progression of endometriosis in a murine model

Chen, Qiong-Hua ; Zhou, Wei-Dong ; Pu, De-Min ; Huang, Qian-Sheng ; Li, Tian ; Chen, Qing-Xi

United States

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