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11-deoxy prostaglandin F2α , a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3(−/−) females

Ye, Xiaoqin, M.D., Ph.D ; Diao, Honglu, Ph.D ; Chun, Jerold, M.D., Ph.D

Fertility and sterility, 2012-03, Vol.97 (3), p.757-763 [Periódico revisado por pares]

Elsevier Inc

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  • Título:
    11-deoxy prostaglandin F2α , a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3(−/−) females
  • Autor: Ye, Xiaoqin, M.D., Ph.D ; Diao, Honglu, Ph.D ; Chun, Jerold, M.D., Ph.D
  • Assuntos: 11-deoxy PGF2α ; agonists ; animal models ; birth weight ; COX-derived prostanoids ; embryo implantation ; embryo spacing ; females ; Internal Medicine ; litter size ; Lysophosphatidic acid (LPA) receptor 3 ; mice ; Obstetrics and Gynecology ; pregnancy outcome ; prostaglandins ; prostanoid receptor agonists ; prostanoid receptors ; spatial distribution ; thromboxanes ; uterus
  • É parte de: Fertility and sterility, 2012-03, Vol.97 (3), p.757-763
  • Notas: http://dx.doi.org/10.1016/j.fertnstert.2011.12.004
  • Descrição: Objective To determine cyclooxygenase-derived prostanoid signaling in alleviating embryo crowding in the Lpar3(−/−) females. Design Experimental mouse model. Setting Research laboratories. Animal(s) Wild-type, Lpar3(+/−) , and Lpar3(−/−) mice. Intervention(s) Intraperitoneal (IP) administration of prostaglandin E2 (PGE2 ), cPGI (a stable analogue of PGI2 ), and 11-deoxy prostaglandin F2α (11-deoxy PGF2α , a thromboxane A2 receptor agonist) to preimplantation gestation day 3.5 Lpar3(−/−) females. Main Outcome Measure(s) Implantation sites were detected by blue dye reaction and embryo spacing was determined by the distribution of the implantation sites along the uterine horns on gestation day 4.5; pregnancy outcome was measured by litter size at birth. Result(s) Administration of PGE2 + cPGI on gestation day 3.5 Lpar3(−/−) females restored on-time implantation but did not affect embryo spacing or the number of implantation sites detected on gestation day 4.5; PGE2 + cPGI treatment increased litter size at birth. Administration of PGE2 + cPGI + 11-deoxy PGF2α on gestation day 3.5 Lpar3(−/−) females rescued on-time implantation, partially dispersed the clustered implantation sites normally observed in the Lpar3(−/−) females, increased the number of implantation sites detected on gestation day 4.5, and increased litter size at birth. Conclusion(s) The thromboxane A2 receptor agonist 11-deoxy PGF2α can partially alleviate embryo crowding in the Lpar3(−/−) females and embryo crowding likely contributes to reduced litter size in the Lpar3(−/−) females.
  • Editor: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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