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Performance of at-home self-collected saliva and nasal-oropharyngeal swabs in the surveillance of COVID-19

Braz-Silva, Paulo H. ; Mamana, Ana C. ; Romano, Camila M. ; Felix, Alvina C. ; de Paula, Anderson V. ; Fereira, Noeli E ; Buss, Lewis F. ; Tozetto-Mendoza, Tania R. ; Caixeta, Rafael A. V. ; Leal, Fabio E. ; Grespan, Regina M. Z. ; Bizário, João C. S. ; Ferraz, Andrea B. C. ; Sapkota, Dipak ; Giannecchini, Simone ; To, Kelvin K. ; Doglio, Alain ; Mendes-Correa, Maria C.

Journal of oral microbiology, 2021-01, Vol.13 (1), p.1858002-1858002 [Periódico revisado por pares]

United States: Taylor & Francis

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  • Título:
    Performance of at-home self-collected saliva and nasal-oropharyngeal swabs in the surveillance of COVID-19
  • Autor: Braz-Silva, Paulo H. ; Mamana, Ana C. ; Romano, Camila M. ; Felix, Alvina C. ; de Paula, Anderson V. ; Fereira, Noeli E ; Buss, Lewis F. ; Tozetto-Mendoza, Tania R. ; Caixeta, Rafael A. V. ; Leal, Fabio E. ; Grespan, Regina M. Z. ; Bizário, João C. S. ; Ferraz, Andrea B. C. ; Sapkota, Dipak ; Giannecchini, Simone ; To, Kelvin K. ; Doglio, Alain ; Mendes-Correa, Maria C.
  • Assuntos: coronavirus ; infection control ; Original ; PCR ; primary health care ; Saliva ; telemedicine
  • É parte de: Journal of oral microbiology, 2021-01, Vol.13 (1), p.1858002-1858002
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Background: SARS-CoV-2 quickly spreads in the worldwide population, imposing social restrictions to control the infection, being the massive testing another essential strategy to break the chain of transmission. Aim: To compare the performance of at-home self-collected samples - saliva and combined nasal-oropharyngeal swabs (NOP) - for SARS-CoV-2 detection in a telemedicine platform for COVID-19 surveillance. Material and methods: We analyzed 201 patients who met the criteria of suspected COVID-19. NOP sampling was combined (nostrils and oropharynx) and saliva collected using a cotton pad device. Detection of SARS-COV-2 was performed by using the Altona RealStar® SARS-CoV-2 RT-PCR Kit 1.0.  Results: There was an overall significant agreement (κ coefficient value of 0.58) between saliva and NOP. Considering results in either sample, 70 patients positive for SARS-CoV-2 were identified, with 52/70 being positive in NOP and 55/70 in saliva. This corresponds to sensitivities of 74.2% (95% CI; 63.7% to 83.1%) for NOP and 78.6% (95% CI; 67.6% to 86.6%) for saliva. Conclusion: Our data show the feasibility of using at-home self-collected samples (especially saliva), as an adequate alternative for SARS-CoV-2 detection. This new approach of testing can be useful to develop strategies for COVID-19 surveillance and for guiding public health decisions.
  • Editor: United States: Taylor & Francis
  • Idioma: Inglês;Norueguês
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