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Antimicrobial postexposure prophylaxis for anthrax: adverse events and adherence

Shepard, Colin W ; Soriano-Gabarro, Montse ; Zell, Elizabeth R ; Hayslett, James ; Lukacs, Susan ; Goldstein, Susan ; Factor, Stephanie ; Jones, Joshua ; Ridzon, Renee ; Williams, Ian ; Rosenstein, Nancy

Emerging infectious diseases, 2002-10, Vol.8 (10), p.1124-1132 [Periódico revisado por pares]

United States: U.S. National Center for Infectious Diseases

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Título:
Antimicrobial postexposure prophylaxis for anthrax: adverse events and adherence
Autor: Shepard, Colin W ; Soriano-Gabarro, Montse ; Zell, Elizabeth R ; Hayslett, James ; Lukacs, Susan ; Goldstein, Susan ; Factor, Stephanie ; Jones, Joshua ; Ridzon, Renee ; Williams, Ian ; Rosenstein, Nancy
Assuntos: adherence ; Adolescent ; Adult ; adverse events ; Aged ; Aged, 80 and over ; Amoxicillin - administration & dosage ; Amoxicillin - adverse effects ; Amoxicillin - therapeutic use ; Anthrax ; Anthrax - drug therapy ; Anthrax - prevention & control ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - adverse effects ; Anti-Bacterial Agents - therapeutic use ; Anti-Infective Agents - administration & dosage ; Anti-Infective Agents - adverse effects ; Anti-Infective Agents - therapeutic use ; Antibiotic Prophylaxis ; antimicrobial prophylaxis ; Bacillus anthracis ; Bioterrorism ; Ciprofloxacin - administration & dosage ; Ciprofloxacin - adverse effects ; Ciprofloxacin - therapeutic use ; Dispatch ; District of Columbia ; Doxycycline - administration & dosage ; Doxycycline - adverse effects ; Doxycycline - therapeutic use ; Drug Administration Schedule ; Ethnic Groups ; Female ; Health aspects ; Humans ; Male ; Middle Aged ; New York City ; Patient Compliance ; Penicillins - administration & dosage ; Penicillins - adverse effects ; Penicillins - therapeutic use ; Physiological aspects ; Prevention ; Risk Factors ; Treatment Refusal ; United States
É parte de: Emerging infectious diseases, 2002-10, Vol.8 (10), p.1124-1132
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: We collected data during postexposure antimicrobial prophylaxis campaigns and from a prophylaxis program evaluation 60 days after start of antimicrobial prophylaxis involving persons from six U.S. sites where Bacillus anthracis exposures occurred. Adverse events associated with antimicrobial prophylaxis to prevent anthrax were commonly reported, but hospitalizations and serious adverse events as defined by Food and Drug Administration criteria were rare. Overall adherence during 60 days of antimicrobial prophylaxis was poor (44%), ranging from 21% of persons exposed in the Morgan postal facility in New York City to 64% of persons exposed at the Brentwood postal facility in Washington, D.C. Adherence was highest among participants in an investigational new drug protocol to receive additional antibiotics with or without anthrax vaccine--a likely surrogate for anthrax risk perception. Adherence of <60 days was not consistently associated with adverse events.
Editor: United States: U.S. National Center for Infectious Diseases
Idioma: Inglês

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Antimicrobial postexposure prophylaxis for anthrax: adverse events and adherence

Shepard, Colin W ; Soriano-Gabarro, Montse ; Zell, Elizabeth R ; Hayslett, James ; Lukacs, Susan ; Goldstein, Susan ; Factor, Stephanie ; Jones, Joshua ; Ridzon, Renee ; Williams, Ian ; Rosenstein, Nancy

United States: U.S. National Center for Infectious Diseases

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