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Altered Fatty Acid Metabolism in Long Duration Road Transport: An NMR-based Metabonomics Study in Sheep

Li, Juan ; Wijffels, Gene ; Yu, Yihua ; Nielsen, Lars K ; Niemeyer, Dominic O ; Fisher, Andrew D ; Ferguson, Drewe M ; Schirra, Horst Joachim

Journal of proteome research, 2011-03, Vol.10 (3), p.1073-1087 [Periódico revisado por pares]

United States: American Chemical Society

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Altered Fatty Acid Metabolism in Long Duration Road Transport: An NMR-based Metabonomics Study in Sheep
Autor: Li, Juan ; Wijffels, Gene ; Yu, Yihua ; Nielsen, Lars K ; Niemeyer, Dominic O ; Fisher, Andrew D ; Ferguson, Drewe M ; Schirra, Horst Joachim
Assuntos: Amino Acids - metabolism ; Animals ; Blood Chemical Analysis - methods ; Carbohydrate Metabolism ; Fatty Acids - metabolism ; Female ; Lipid Metabolism ; Livestock ; Metabolomics - methods ; Motor Vehicles ; Nuclear Magnetic Resonance, Biomolecular - methods ; Sheep - metabolism ; Stress, Physiological ; Stress, Psychological ; Transportation ; Urinalysis - methods
É parte de: Journal of proteome research, 2011-03, Vol.10 (3), p.1073-1087
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The physical, endocrine, and metabolic responses of livestock to road transport have been evaluated by conventional hematological and biochemistry parameters for more than 20 years. However, these measures are relatively insensitive to subtle metabolic adaptations. We applied NMR-based metabonomics to assess system-wide metabolic responses as expressed in urine and serum of a large cohort of animals (n = 80) subjected to 12 and 48 h road transport. The profiling of 1H NMR spectra revealed that the transported animals experienced altered gut and energy metabolism, muscle catabolism, and possibly a renal response. The animals transported for 48 h exhibited a deeper metabolic response to the transport event and a complex and expanded metabolic trajectory over the 72 h recovery period. Intriguingly, excretion of acyl glycines and a dicarboxylic acid was observed after transport and during recovery, implicating peroxisomal fatty acid oxidation as a metabolic response to transport-induced stress.
Editor: United States: American Chemical Society
Idioma: Inglês

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Altered Fatty Acid Metabolism in Long Duration Road Transport: An NMR-based Metabonomics Study in Sheep

Li, Juan ; Wijffels, Gene ; Yu, Yihua ; Nielsen, Lars K ; Niemeyer, Dominic O ; Fisher, Andrew D ; Ferguson, Drewe M ; Schirra, Horst Joachim

United States: American Chemical Society

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