Idioma:

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

Whitmire, Paula ; Rickertsen, Cassandra R ; Hawkins-Daarud, Andrea ; Carrasco, Jr, Eduardo ; Lorence, Julia ; De Leon, Gustavo ; Curtin, Lee ; Bayless, Spencer ; Clark-Swanson, Kamala ; Peeri, Noah C ; Corpuz, Christina ; Lewis-de Los Angeles, Christine Paula ; Bendok, Bernard R ; Gonzalez-Cuyar, Luis ; Vora, Sujay ; Mrugala, Maciej M ; Hu, Leland S ; Wang, Lei ; Porter, Alyx ; Kumthekar, Priya ; Johnston, Sandra K ; Egan, Kathleen M ; Gatenby, Robert ; Canoll, Peter ; Rubin, Joshua B ; Swanson, Kristin R

BMC cancer, 2020-05, Vol.20 (1), p.447-10, Article 447 [Periódico revisado por pares]

England: BioMed Central Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients
Autor: Whitmire, Paula ; Rickertsen, Cassandra R ; Hawkins-Daarud, Andrea ; Carrasco, Jr, Eduardo ; Lorence, Julia ; De Leon, Gustavo ; Curtin, Lee ; Bayless, Spencer ; Clark-Swanson, Kamala ; Peeri, Noah C ; Corpuz, Christina ; Lewis-de Los Angeles, Christine Paula ; Bendok, Bernard R ; Gonzalez-Cuyar, Luis ; Vora, Sujay ; Mrugala, Maciej M ; Hu, Leland S ; Wang, Lei ; Porter, Alyx ; Kumthekar, Priya ; Johnston, Sandra K ; Egan, Kathleen M ; Gatenby, Robert ; Canoll, Peter ; Rubin, Joshua B ; Swanson, Kristin R
Assuntos: Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Biomathematical models ; Brain cancer ; Brain Neoplasms - mortality ; Brain Neoplasms - pathology ; Brain Neoplasms - therapy ; Cell survival ; Child ; Female ; Females ; Follow-Up Studies ; Glioblastoma ; Glioblastoma - mortality ; Glioblastoma - pathology ; Glioblastoma - therapy ; Glioblastoma multiforme ; Glioblastomas ; Humans ; Image Interpretation, Computer-Assisted ; Institutional repositories ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Males ; Medical research ; Medicine, Experimental ; Middle Aged ; Models, Theoretical ; Neuroimaging ; Patient outcomes ; Patients ; Prognosis ; Retrospective Studies ; Sex ; Sex differences ; Sex Factors ; Short term ; Survival analysis ; Survival Rate ; Tumors ; Young Adult
É parte de: BMC cancer, 2020-05, Vol.20 (1), p.447-10, Article 447
Descrição: Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences. Combining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females). Among males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test). Despite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
Editor: England: BioMed Central Ltd
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients

England: BioMed Central Ltd

Buscando em bases de dados remotas. Favor aguardar.