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Silver nanoparticles in diabetes mellitus: therapeutic potential and mechanistic insights

Paul, Susanta ; Sarkar, Ishita ; Sarkar, Nilanjan ; Bose, Anannya ; Chakraborty, Mainak ; Chakraborty, Amrita ; Mukherjee, Swarupananda

Bulletin of the National Research Centre, 2024-12, Vol.48 (1), p.33-17, Article 33 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Silver nanoparticles in diabetes mellitus: therapeutic potential and mechanistic insights
Autor: Paul, Susanta ; Sarkar, Ishita ; Sarkar, Nilanjan ; Bose, Anannya ; Chakraborty, Mainak ; Chakraborty, Amrita ; Mukherjee, Swarupananda
Assuntos: Agriculture ; Anti-diabetic activity ; Antioxidants ; Beta cells ; Bioavailability ; Biocompatibility ; Biomedical materials ; Blood levels ; Blood sugar ; Characterization methods ; Development and progression ; Diabetes ; Diabetes mellitus ; Engineering ; Global health ; Health aspects ; Humanities and Social Sciences ; Hyperglycemia ; Hypoglycemic agents ; Inflammation ; Insulin ; Insulin resistance ; Medical innovations ; multidisciplinary ; Nanoparticles ; Nanotechnology ; Optimization ; Oxidation resistance ; Oxidative stress ; Pathogenesis ; Pharmaceutical Industries ; Physicochemical properties ; Polyphenols ; Public health ; Review ; Safety ; Science ; Science (multidisciplinary) ; Sensitivity enhancement ; Side effects ; Silver ; Silver nanoparticles ; Therapeutic applications ; Therapeutic potential ; Toxicity ; Type 2 diabetes ; World health
É parte de: Bulletin of the National Research Centre, 2024-12, Vol.48 (1), p.33-17, Article 33
Descrição: Background Research on the use of silver nanoparticles in the context of diabetes mellitus has gained attention due to the unique properties of these nanoparticles, such as their antimicrobial, anti-inflammatory, and antioxidant characteristics. While the field is still in its early stages, several studies have explored the potential applications and effects of silver nanoparticles in managing diabetes. Main body of the abstract Diabetes mellitus, a global health concern marked by impaired insulin function and high blood glucose levels, has spurred innovative therapeutic investigations, including nanotechnology. Silver nanoparticles have emerged as promising candidates in this pursuit. This abstract provides an overview of current research on silver nanoparticles’ application in managing diabetes mellitus, highlighting their therapeutic potential and mechanisms of action. With unique physicochemical properties like high surface area and bio-compatibility, silver nanoparticles are ideal for diverse biomedical applications. Recent studies show their ability to modulate key pathways in diabetes pathogenesis, enhancing insulin sensitivity, reducing oxidative stress, and supporting pancreatic beta-cell function. Their antimicrobial properties are particularly beneficial for diabetes patients prone to infections. Moreover, using silver nanoparticle-based carriers for anti-diabetic drugs improves drug bio-availability and reduces side effects, potentially enhancing conventional medication efficacy. However, addressing safety and toxicity concerns is crucial. Ongoing research focuses on optimizing nanoparticle size, shape, and surface modifications to enhance bio-compatibility and minimize adverse effects. Short conclusion In conclusion, silver nanoparticles represent a novel and multifaceted approach in the management of diabetes mellitus. Their ability to target multiple facets of diabetes pathogenesis, including insulin resistance, oxidative stress, and inflammation, positions them as potential candidates for future therapeutic interventions. However, further research is warranted to elucidate their long-term safety profile and optimize their application in clinical settings.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Silver nanoparticles in diabetes mellitus: therapeutic potential and mechanistic insights

Paul, Susanta ; Sarkar, Ishita ; Sarkar, Nilanjan ; Bose, Anannya ; Chakraborty, Mainak ; Chakraborty, Amrita ; Mukherjee, Swarupananda

Berlin/Heidelberg: Springer Berlin Heidelberg

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