skip to main content
Idioma:

Effects of long-term PPI treatment on producing bowel symptoms and SIBO

Compare, Debora ; Pica, Loredana ; Rocco, Alba ; De Giorgi, Francesco ; Cuomo, Rosario ; Sarnelli, Giovanni ; Romano, Marco ; Nardone, Gerardo

European journal of clinical investigation, 2011-04, Vol.41 (4), p.380-386 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

Texto completo disponível

Citações Citado por
  • Título:
    Effects of long-term PPI treatment on producing bowel symptoms and SIBO
  • Autor: Compare, Debora ; Pica, Loredana ; Rocco, Alba ; De Giorgi, Francesco ; Cuomo, Rosario ; Sarnelli, Giovanni ; Romano, Marco ; Nardone, Gerardo
  • Assuntos: Adult ; Biological and medical sciences ; Esomeprazole - adverse effects ; Female ; Gastroesophageal Reflux - drug therapy ; Gastroesophageal Reflux - physiopathology ; General aspects ; GERD ; Humans ; IBS ; Intestines - drug effects ; Intestines - microbiology ; Irritable Bowel Syndrome - chemically induced ; Irritable Bowel Syndrome - physiopathology ; Italy ; Male ; Medical sciences ; Middle Aged ; NERD ; PPIs ; Proton Pump Inhibitors - adverse effects ; SIBO ; Time Factors
  • É parte de: European journal of clinical investigation, 2011-04, Vol.41 (4), p.380-386
  • Notas: ark:/67375/WNG-Z53SGK02-N
    istex:AA3B6EE6486E1A6F8FB6DDE6D701F5D94CE46990
    ArticleID:ECI2419
    M. Romano and G. Nardone contributed equally to this work.
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Eur J Clin Invest 2011; 41 (4): 380–386 Background  Gastroesophageal reflux disease (GERD), including erosive reflux disease and non‐erosive reflux disease (NERD), is a chronic disease with a significant negative effect on quality of life. State‐of‐the‐art treatment involves proton pump inhibitors (PPIs). However, relapse of symptoms occurs in the majority of the patients who require recurrent or continuous therapy. Although PPIs are well tolerated, little information is available about gastrointestinal side effects. Aim  To evaluate the effects of long‐term PPI treatment on development of bowel symptoms and/or small intestinal bacterial overgrowth (SIBO). Methods  Patients with NERD not complaining of bowel symptoms were selected by upper endoscopy, 24‐h pH‐metry and a structured questionnaire concerning severity and frequency of bloating, flatulence, abdominal pain, diarrhoea and constipation. Patients were treated with esomeprazole 20 mg bid for 6 months. Prior to and after 8 weeks and 6 months of therapy, patients received the structured questionnaire and underwent evaluation of SIBO by glucose hydrogen breath test (GHBT). Results  Forty‐two patients with NERD were selected out of 554 eligible patients. After 8 weeks of PPI treatment, patients complained of bloating, flatulence, abdominal pain and diarrhoea in 43%, 17%, 7% and 2%, respectively. After 6 months, the incidence of bowel symptoms further increased and GHBT was found positive in 11/42 (26%) patients. By a post hoc analysis, a significant (P < 0·05) percentage of patients (8/42) met Rome III criteria for irritable bowel syndrome. Conclusions  Prolonged PPI treatment may produce bowel symptoms and SIBO; therefore, the strategy of step‐down or on‐demand PPI therapy should be encouraged in GERD.
  • Editor: Oxford, UK: Blackwell Publishing Ltd
  • Idioma: Inglês
Links
Voltar para lista de resultados
Resultado  1 AvançarIr para próxima página

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.