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Ca2+ flux through promiscuous cardiac Na+ channels : Slip-mode conductance

SANTANA, L. F ; GOMEZ, A. M ; LEDERER, W. J

Science (American Association for the Advancement of Science), 1998-02, Vol.279 (5353), p.1027-1033 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Ca2+ flux through promiscuous cardiac Na+ channels : Slip-mode conductance
Autor: SANTANA, L. F ; GOMEZ, A. M ; LEDERER, W. J
Assuntos: Action Potentials ; Animals ; Biochemistry ; Biological and medical sciences ; Calcium ; Calcium - metabolism ; Cardiology and cardiovascular system ; Cardiotonic Agents - pharmacology ; Cell physiology ; Cellular biology ; Cellular signal transduction ; Contraction ; Cyclic AMP - metabolism ; Cyclic AMP-Dependent Protein Kinases - metabolism ; Digoxin - pharmacology ; Enzyme Activation ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Heart ; Heart contraction ; Human health and pathology ; In Vitro Techniques ; Ion Channel Gating ; Ions ; Isoproterenol - pharmacology ; Life Sciences ; Molecular and cellular biology ; Muscle contraction ; Myocardial Contraction - physiology ; Myocardium - cytology ; Myocardium - metabolism ; Ouabain - pharmacology ; Patch-Clamp Techniques ; Proteins ; Rats ; Receptors, Adrenergic, beta - physiology ; Rodents ; Ryanodine Receptor Calcium Release Channel - metabolism ; Sarcoplasmic Reticulum - metabolism ; Signal Transduction ; Sodium ; Sodium - metabolism ; Sodium Channel Blockers ; Sodium channels ; Sodium Channels - drug effects ; Sodium Channels - metabolism ; Sodium-Calcium Exchanger - metabolism ; Tetrodotoxin - pharmacology
É parte de: Science (American Association for the Advancement of Science), 1998-02, Vol.279 (5353), p.1027-1033
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: The tetrodotoxin-sensitive sodium ion (Na+) channel is opened by cellular depolarization and favors the passage of Na+ over other ions. Activation of the beta-adrenergic receptor or protein kinase A in rat heart cells transformed this Na+ channel into one that is promiscuous with respect to ion selectivity, permitting calcium ions (Ca2+) to permeate as readily as Na+. Similarly, nanomolar concentrations of cardiotonic steroids such as ouabain and digoxin switched the ion selectivity of the Na+ channel to this state of promiscuous permeability called slip-mode conductance. Slip-mode conductance of the Na+ channel can contribute significantly to local and global cardiac Ca2+ signaling and may be a general signaling mechanism in excitable cells.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Ca2+ flux through promiscuous cardiac Na+ channels : Slip-mode conductance

SANTANA, L. F ; GOMEZ, A. M ; LEDERER, W. J

Washington, DC: American Association for the Advancement of Science

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