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Ivermectin reduces sexual behavior in female rats
Moreira, N ; Bernardi, M.M ; Spinosa, H.S
Neurotoxicology and teratology, 2014-05, Vol.43, p.33-38
[Periódico revisado por pares]
United States: Elsevier Inc
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Título:
Ivermectin reduces sexual behavior in female rats
Autor:
Moreira, N
;
Bernardi, M.M
;
Spinosa, H.S
Assuntos:
Animals
;
Avermectins
;
Contraceptive Agents - pharmacology
;
Dose-Response Relationship, Drug
;
Emergency
;
Estradiol - analogs & derivatives
;
Estradiol - pharmacology
;
Estrogen-induced sexual behavior
;
Estrus
;
Female
;
Insecticides - pharmacology
;
Intensity of lordosis
;
Ivermectin - pharmacology
;
Lordosis quotient
;
Male
;
Medical Education
;
Rats
;
Rats, Wistar
;
Sexual Behavior, Animal - drug effects
;
Statistics, Nonparametric
É parte de:
Neurotoxicology and teratology, 2014-05, Vol.43, p.33-38
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
Abstract Ivermectin (IVM) is an antiparasitic drug that is widely used in domestic animals. In mammals, IVM acts as a γ-aminobutyric acid (GABA) receptor agonist. This neurotransmitter plays an important role in the regulation of female sexual behavior. The present study investigated the effects of therapeutic (0.2 mg/kg) and high (1.0 mg/kg) IVM doses on female sexual behavior in physiological and pharmacological conditions. Female rats in estrus or treated with estradiol valerate to induce sexual behavior 24 h before the experiments were used. Ivermectin was administered 15 min before the sexual observations. The number of lordosis events in 10 mounts was recorded to calculate the lordosis quotient. The intensity of lordosis (0 [no lordosis], 1 [low lordosis], 2 [normal lordosis] and 3 [exaggerated lordosis]) was scored. In estrus and hormonal treated female rats, both IVM doses decreased the intensity of the lordosis reflex and the percentage of females that presented high levels of lordosis (exaggerated lordosis). However, the number of females that presented lordosis was unaltered. We conclude that in both hormonal conditions, 0.2 mg/kg IVM treatment reduced female sexual behavior and the execution of the lordosis reflex. The present results may be useful for avoiding the side effects of this drug in veterinary practice.
Editor:
United States: Elsevier Inc
Idioma:
Inglês
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