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Anti-caries evaluation of a nano-hydroxyapatite dental lotion for use after toothbrushing: An in situ study

Amaechi, Bennett T. ; Alshareif, Dina O. ; Azees, Parveez A. Abdul ; Shehata, Marina A. ; Lima, Patricia P. ; Abdollahi, Azadeh ; Kalkhorani, Parisa S. ; Evans, Veronica ; Bagheri, Ariana ; Okoye, Linda O.

Journal of dentistry, 2021-12, Vol.115, p.103863-103863, Article 103863 [Periódico revisado por pares]

England: Elsevier Ltd

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Anti-caries evaluation of a nano-hydroxyapatite dental lotion for use after toothbrushing: An in situ study
Autor: Amaechi, Bennett T. ; Alshareif, Dina O. ; Azees, Parveez A. Abdul ; Shehata, Marina A. ; Lima, Patricia P. ; Abdollahi, Azadeh ; Kalkhorani, Parisa S. ; Evans, Veronica ; Bagheri, Ariana ; Okoye, Linda O.
Assuntos: Adult ; Antibiotics ; Anticaries ; Brushing ; Cariostatic Agents - pharmacology ; Cariostatic Agents - therapeutic use ; Clinical trials ; Demineralization ; Demineralizing ; Dental caries ; Dental Caries - drug therapy ; Dental Caries - prevention & control ; Dental enamel ; Dental lotion ; Dental materials ; Dentifrices ; Dentistry ; Dietary minerals ; Durapatite - pharmacology ; Durapatite - therapeutic use ; Enamel ; Fluorides ; Fluorides - therapeutic use ; Humans ; Hydroxyapatite ; Hypotheses ; Informed consent ; Lotions ; Microradiography ; Nano-hydroxyapatite ; Oral hygiene ; Placebos ; Remineralization ; Risk assessment ; Sound ; Teeth ; Tooth Remineralization - methods ; Toothbrushing ; Toothbrushing - methods ; Toothpaste ; Toothpastes - pharmacology ; Toothpastes - therapeutic use
É parte de: Journal of dentistry, 2021-12, Vol.115, p.103863-103863, Article 103863
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-News-1
ObjectType-Feature-3
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Descrição: •The application of 5% nanoHAP-containing dental lotion immediately following toothbrushing with 5% nanoHAP toothpaste:.•enhanced the efficacy of 5% nanoHAP toothpaste in remineralizing initial caries lesions.•may offer additional protection against tooth decay.•The present study provides further evidence that the use of 5% nanoHAP toothpaste alone promotes caries remineralization. The aim of this randomized, double-blind, two-arm crossover in situ study was to investigate whether nano-hydroxyapatite (nanoHAP) dental lotion (Apagard Deep Care) applied immediately after tooth-brushing with nanoHAP toothpaste (Apagard M-plus) enhances the remineralization promotion and the demineralization inhibition efficacies of nanoHAP toothpastes. 64 sound enamel blocks and 64 blocks bearing artificially-produced initial caries were produced from human permanent molar teeth. During each treatment period, lasting 14 days per arm, two blocks, one sound and one lesion-bearing, were exposed to either 5% nanoHAP-containing or placebo dental lotion after tooth-brushing with 5% nanoHAP toothpaste, via an intra-oral appliance worn by 30 adults in each of the study groups. Baseline and post-test mineral loss were quantified using transverse microradiography (TMR). One-sided t-test of one group mean was used for intragroup comparison, while two-sided t-test of two independent means was used to compare the two dental lotions. Pairwise comparison (baseline vs. post-test) indicated significant (p<.001) remineralization by nanoHAP toothpaste in both groups. However, when compared against each other, there was a significantly (p<.001) greater percentage of remineralization with nanoHAP lotion [58.4(±1.8)%] than with placebo lotion [37.7(±2.2)%]. TMR examination showed absolute demineralization inhibition in sound enamel blocks exposed to either lotions. Toothpaste containing 5% nanoHAP effectively remineralized initial caries and inhibited demineralization of healthy enamel; however, the application of a dental lotion containing 5% nanoHAP after brushing resulted in superior remineralization compared to a placebo lotion. Dental lotion containing 5% nanohydroxyapatite used immediately after toothbrushing with 5% nanohydroxyapatite toothpaste can serve as an adjunct to enhance the clinical benefits of the toothpaste.
Editor: England: Elsevier Ltd
Idioma: Inglês

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Anti-caries evaluation of a nano-hydroxyapatite dental lotion for use after toothbrushing: An in situ study

Amaechi, Bennett T. ; Alshareif, Dina O. ; Azees, Parveez A. Abdul ; Shehata, Marina A. ; Lima, Patricia P. ; Abdollahi, Azadeh ; Kalkhorani, Parisa S. ; Evans, Veronica ; Bagheri, Ariana ; Okoye, Linda O.

England: Elsevier Ltd

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