Idioma:

Fatal intoxication involving 2‐methyl AP‐237

Truver, Michael T. ; Crosby, Michele M. ; Gillette, Alex T. ; Brogan, Sara C. ; Hoyer, Jennifer L. ; Chronister, Chris W. ; Broussard, Wilson A. ; Vega, Russell S. ; Goldberger, Bruce A.

Journal of forensic sciences, 2023-07, Vol.68 (4), p.1419-1424 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Fatal intoxication involving 2‐methyl AP‐237
Autor: Truver, Michael T. ; Crosby, Michele M. ; Gillette, Alex T. ; Brogan, Sara C. ; Hoyer, Jennifer L. ; Chronister, Chris W. ; Broussard, Wilson A. ; Vega, Russell S. ; Goldberger, Bruce A.
Assuntos: 2MAP ; 2‐methyl AP‐237 ; 2‐methyl buccinazine ; Analgesics, Opioid - analysis ; Autopsies ; Blood ; Chromatography ; cinnamyl piperazines ; Containers ; Drug overdose ; Drug Overdose - diagnosis ; Fentanyl - analysis ; Gas chromatography ; Gas Chromatography-Mass Spectrometry ; Humans ; Intoxication ; Liquid chromatography ; Male ; Mass spectrometry ; Metabolites ; Middle Aged ; Narcotics ; novel synthetic opioid ; postmortem ; Quadrupoles ; Scientific imaging ; Urine
É parte de: Journal of forensic sciences, 2023-07, Vol.68 (4), p.1419-1424
Notas: Presented at the 74th Annual Scientific Conference of the American Academy of Forensic Sciences, February 21‐26, 2022, in Seattle, WA.
Descrição: Novel synthetic opioids contribute considerably to the opioid epidemic, especially with the frequent emergence of structurally similar compounds. This case report describes a fatal intoxication involving 2‐methyl AP‐237. A 54‐year‐old Caucasian male was found deceased from an apparent drug overdose. A plastic container labeled “2MAP” and a cut straw were found in the decedent's backpack at the scene. A white substance found in the container tested positive for fentanyl by field testing. According to his medical history, the decedent was treated for a drug overdose 3 years prior to his death. With no diagnostic findings at autopsy, the case was submitted for toxicological analysis. An unknown substance was detected in peripheral blood and urine using gas chromatography with nitrogen phosphorous detection (GC‐NPD). Further testing was conducted using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography‐quadrupole‐time‐of‐flight mass spectrometry (LC‐QTOF‐MS) which confirmed the presence of 2‐methyl AP‐237 and potential metabolites in blood and urine. Quantitation by GC‐NPD revealed concentrations of 2‐methyl AP‐237 in blood and urine at 480 ng/mL and 4200 ng/mL, respectively. The toxicological analysis also identified and quantitated alprazolam in the blood at 55 ng/mL. Additionally, the metabolism of 2‐methyl AP‐237 was investigated and three hydroxylated metabolites were identified in peripheral blood and urine. Limited literature is available for the detection and quantitation of 2‐methyl AP‐237 in postmortem specimens. Given the toxicological findings with unremarkable autopsy findings, this case is an example of a fatal intoxication involving 2‐methyl AP‐237.
Editor: United States: Wiley Subscription Services, Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Fatal intoxication involving 2‐methyl AP‐237

Truver, Michael T. ; Crosby, Michele M. ; Gillette, Alex T. ; Brogan, Sara C. ; Hoyer, Jennifer L. ; Chronister, Chris W. ; Broussard, Wilson A. ; Vega, Russell S. ; Goldberger, Bruce A.

United States: Wiley Subscription Services, Inc

Buscando em bases de dados remotas. Favor aguardar.