Idioma:

Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)

AOUDJHANE, M ; LABOPIN, M ; SHOUTEN, H ; BLAISE, D ; FALDA, M ; FAUSER, A. A ; ESTEVE, J ; POLGE, E ; SLAVIN, S ; NIEDERWIESER, D ; NAGLER, A ; ROCHA, V ; GORIN, N. C ; SHIMONI, A ; RUUTU, T ; KOLB, H.-J ; FRASSONI, F ; BOIRON, J. M ; YIN, J. L ; FINKE, J

Leukemia, 2005-12, Vol.19 (12), p.2304-2312 [Periódico revisado por pares]

London: Nature Publishing

Texto completo disponível

Citações Citado por

Enviar para

Título:
Comparative outcome of reduced intensity and myeloablative conditioning regimen in HLA identical sibling allogeneic haematopoietic stem cell transplantation for patients older than 50 years of age with acute myeloblastic leukaemia: a retrospective survey from the Acute Leukemia Working Party (ALWP) of the European group for Blood and Marrow Transplantation (EBMT)
Autor: AOUDJHANE, M ; LABOPIN, M ; SHOUTEN, H ; BLAISE, D ; FALDA, M ; FAUSER, A. A ; ESTEVE, J ; POLGE, E ; SLAVIN, S ; NIEDERWIESER, D ; NAGLER, A ; ROCHA, V ; GORIN, N. C ; SHIMONI, A ; RUUTU, T ; KOLB, H.-J ; FRASSONI, F ; BOIRON, J. M ; YIN, J. L ; FINKE, J
Assuntos: Acute myeloid leukemia ; Aged ; Biological and medical sciences ; Blood ; Busulfan ; Cause of Death ; Clinical trials ; Conditioning ; Cytogenetics ; Dose-Response Relationship, Drug ; Dose-Response Relationship, Radiation ; Female ; Fludarabine ; Graft vs Host Disease - etiology ; Graft-versus-host reaction ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation - methods ; Hematopoietic Stem Cell Transplantation - mortality ; Hematopoietic stem cells ; Histocompatibility antigen HLA ; Histocompatibility Testing ; Humans ; Irradiation ; Leukemia ; Leukemia, Myeloid, Acute - therapy ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Patients ; Peripheral blood ; Radiation ; Radiation dosage ; Recurrence ; Registries ; Retrospective Studies ; Siblings ; Stem cell transplantation ; Stem cells ; Survival Analysis ; Transplantation ; Transplantation Conditioning - methods ; Transplantation, Homologous ; Treatment Outcome
É parte de: Leukemia, 2005-12, Vol.19 (12), p.2304-2312
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Results of reduced intensity conditioning regimen (RIC) in the HLA identical haematopoietic stem cell transplantation (HSCT) setting have not been compared to those after myeloablative (MA) regimen HSCT in patients with acute myeloblastic leukaemia (AML) over 50 years of age. With this aim, outcomes of 315 RIC were compared with 407 MA HSCT recipients. The majority of RIC was fludarabine-based regimen associated to busulphan (BU) (53%) or low-dose total body irradiation (24%). Multivariate analyses of outcomes were used adjusting for differences between both groups. The median follow-up was 13 months. Cytogenetics, FAB classification, WBC count at diagnosis and status of the disease at transplant were not statistically different between the two groups. However, RIC patients were older, transplanted more recently, and more frequently with peripheral blood allogeneic stem cells as compared to MA recipients. In multivariate analysis, acute GVHD (II-IV) and transplant-related mortality were significantly decreased (P=0.01 and P<10(-4), respectively) and relapse incidence was significantly higher (P=0.003) after RIC transplantation. Leukaemia-free survival was not statistically different between the two groups. These results may set the grounds for prospective trials comparing RIC with other strategies of treatment in elderly AML.
Editor: London: Nature Publishing
Idioma: Inglês

Links

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

AOUDJHANE, M ; LABOPIN, M ; SHOUTEN, H ; BLAISE, D ; FALDA, M ; FAUSER, A. A ; ESTEVE, J ; POLGE, E ; SLAVIN, S ; NIEDERWIESER, D ; NAGLER, A ; ROCHA, V ; GORIN, N. C ; SHIMONI, A ; RUUTU, T ; KOLB, H.-J ; FRASSONI, F ; BOIRON, J. M ; YIN, J. L ; FINKE, J

London: Nature Publishing

Buscando em bases de dados remotas. Favor aguardar.