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IKK biology

Liu, Fei ; Xia, Yifeng ; Parker, Aaron S. ; Verma, Inder M.

Immunological reviews, 2012-03, Vol.246 (1), p.239-253 [Periódico revisado por pares]

Oxford, UK: Blackwell Publishing Ltd

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Título:
IKK biology
Autor: Liu, Fei ; Xia, Yifeng ; Parker, Aaron S. ; Verma, Inder M.
Assuntos: Animals ; Enzyme Activation ; Humans ; I Kappa B kinase ; I-kappa B Kinase - antagonists & inhibitors ; I-kappa B Kinase - chemistry ; I-kappa B Kinase - genetics ; I-kappa B Kinase - metabolism ; IKK ; IKK protein ; NEMO ; NF- Kappa B protein ; NF-κB ; Protein Kinase Inhibitors - chemistry ; Protein Kinase Inhibitors - pharmacology ; Signal transduction ; Signal Transduction - drug effects
É parte de: Immunological reviews, 2012-03, Vol.246 (1), p.239-253
Notas: istex:03B4EB2B6390A5F136A0D4AAE9D7AF6D740245AF
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Descrição: The inhibitor of nuclear factor‐κB (IκB) kinase (IKK) complex is the master regulator of the NF‐κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus‐specific, and target‐specific event that is essential for the plethora of functions attributed to NF‐κB. More recently, NF‐κB‐independent roles of IKK members have brought increased complexity to its biological function. This review highlights some of the major advances in the studies of the process of IKK activation and the biological roles of IKK family members, with a focus on NF‐κB‐independent functions. Understanding these complex processes is essential for targeting IKK for therapeutics.
Editor: Oxford, UK: Blackwell Publishing Ltd
Idioma: Inglês

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IKK biology

Liu, Fei ; Xia, Yifeng ; Parker, Aaron S. ; Verma, Inder M.

Oxford, UK: Blackwell Publishing Ltd

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