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In vivo synaptic potency, short-term and long-term plasticity at the hippocampal Schaffer collateral-CA1 synapses: Role of different light–dark cycles in male rats

Radahmadi, Maryam ; Salehifard, Kowsar ; Reisi, Parham

Brain research, 2023-10, Vol.1817, p.148514-148514, Article 148514 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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  • Título:
    In vivo synaptic potency, short-term and long-term plasticity at the hippocampal Schaffer collateral-CA1 synapses: Role of different light–dark cycles in male rats
  • Autor: Radahmadi, Maryam ; Salehifard, Kowsar ; Reisi, Parham
  • Assuntos: Adrenal glands weight (AGWs) ; Body weight (BW) ; CA1 ; Corticosterone (CORT) level ; Light–dark (L/D) cycle ; Long-term potentiation (LTP) ; Paired-pulse (PP)
  • É parte de: Brain research, 2023-10, Vol.1817, p.148514-148514, Article 148514
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: [Display omitted] •The L/D cycles (minimum and particularly maximum durations of light) significantly reduced the synaptic potency and synaptic plasticity.•The extreme L/D cycles significantly reduced the synaptic potency and synaptic plasticity.•The changes in paired-pulse with high interpulse intervals were more significant than the changes in other paired-pulse phases.•The CORT levels, adrenal glands, and body weight gain occurred time-independently concerning different L/D lengths. The changes in the light–dark(L/D) cycle could modify cellular mechanisms in some brain regions. The present study compared the effects of various L/D cycles on invivo synaptic potency, short-term and long-term plasticity in the hippocampal CA1 area, adrenal glands weight(AGWs), corticosterone (CORT) levels, and body weight differences(BWD) in male rats. Male rats were assigned into different L/D cycle groups: L4/D20, L8/D16, L12/D12(control), L16/D8, and L20/D4. The slope, amplitude, and the area under curve(AUC) related to the field excitatory postsynaptic potentials(fEPSPs) were assessed, using the input–output(I/O) functions, paired-pulse(PP) responses at different interpulse intervals, and after the induction of long-term potentiation(LTP) in the hippocampal CA1 area. Also, the CORT levels, AGWs, and BWDs were measured in all groups. The slope, amplitude, and AUC of fEPSP in the I/O functions, all three phases of PP, before and after the LTP induction, were significantly decreased in all experimental groups, especially in the L20/D4 and L4/D20 groups. As such, the CORT levels and AGWs were significantly increased in all experimental groups, especially in the L20/D4 group. Overall, the uncommon L/D cycles (minimum and particularly maximum durations of light) significantly reduced the cellular mechanism of learning and memory. Also, downtrends were observed in synaptic potency, as well as short-term and long-term plasticity. The changes in PP with high interpulse intervals, or activity of GABAB receptors, were more significant than the changes in other PP phases with different L/D durations. Additionally, the CORT levels, adrenal glands, and body weight gain occurred time-independently concerning different L/D lengths.
  • Editor: Netherlands: Elsevier B.V
  • Idioma: Inglês
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