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Repositioning of the global epicentre of non-optimal cholesterol

Taddei, Cristina ; Zhou, Bin ; Bixby, Honor ; Carrillo-Larco, Rodrigo M ; Danaei, Goodarz ; Jackson, Rod T ; Farzadfar, Farshad

Nature (London), 2020-06, Vol.582 (7810), p.73-77 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Repositioning of the global epicentre of non-optimal cholesterol
Autor: Taddei, Cristina ; Zhou, Bin ; Bixby, Honor ; Carrillo-Larco, Rodrigo M ; Danaei, Goodarz ; Jackson, Rod T ; Farzadfar, Farshad
Assuntos: 80 and over ; Adolescent ; Adult ; Age ; age distribution ; Aged ; Aged, 80 and over ; Allmän medicin ; Arctic ; Australasia ; Australia and New Zealand ; Basale medisinske, odontologiske og veterinærmedisinske fag: 710 ; Basic medical, dental and veterinary science disciplines: 710 ; Bayes Theorem ; Blood ; Blood cholesterol ; brain ischemia ; Cardiac and Cardiovascular Systems ; Cardiovascular diseases ; cardiovascular mortality ; cardiovascular risk ; chemical compound ; Cholesterol ; cholesterol blood level ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Clinical Medicine ; controlled study ; Demographic aspects ; Development and progression ; Diet ; disease burden ; epidemiology ; Europe ; Family Medicine ; Female ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Forecasts and trends ; geographic distribution ; Greenland ; HDL ; Health aspects ; Health risk assessment ; Health risks ; Health Sciences ; High density lipoprotein ; high density lipoprotein cholesterol ; High income ; high income country ; human ; Humans ; Hypercholesterolemia ; Hypercholesterolemia - blood ; Hypercholesterolemia - epidemiology ; Hypertension ; Hälsovetenskap ; Income ; Individ och samhälle VIDSOC ; Individual and Society VIDSOC ; Internationality ; Kardiologi ; Klinisk medicin ; LDL ; Levels ; Life Sciences ; lipid ; lipid analysis ; lipid blood level ; Lipids ; low income country ; Low income groups ; Male ; Medical and Health Sciences ; Medical disciplines: 700 ; Medicin och hälsovetenskap ; Medisinske Fag: 700 ; Middle Aged ; middle income country ; mortality rate ; Myocardial Ischemia ; Myocardial Ischemia - blood ; Myocardial Ischemia - epidemiology ; North America ; Nutrition ; population research ; Population studies ; priority journal ; protein ; public health ; Public Health, Global Health, Social Medicine and Epidemiology ; Santé publique et épidémiologie ; sex ratio ; Southeast Asia ; Stroke ; Stroke - blood ; Stroke - epidemiology ; trend study ; Trends ; Triglycerides ; Triglycerides - blood ; VDP ; Women ; Young Adult
É parte de: Nature (London), 2020-06, Vol.582 (7810), p.73-77
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Nature
PMCID: PMC7332422
Descrição: High blood cholesterol is typically considered a feature of wealthy western countries . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health . However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment throughout the world.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Repositioning of the global epicentre of non-optimal cholesterol

Taddei, Cristina ; Zhou, Bin ; Bixby, Honor ; Carrillo-Larco, Rodrigo M ; Danaei, Goodarz ; Jackson, Rod T ; Farzadfar, Farshad

England: Nature Publishing Group

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