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Previous Antiretroviral Therapy for Prevention of Mother-to-Child Transmission of HIV Does not Hamper the Initial Response to PI-Based Multitherapy During Subsequent Pregnancy

Briand, Nelly ; Mandelbrot, Laurent ; Blanche, Stéphane ; Tubiana, Roland ; Faye, Albert ; Dollfus, Catherine ; Le Chenadec, Jérôme ; Benhammou, Valérie ; Rouzioux, Christine ; Warszawski, Josiane

Journal of acquired immune deficiency syndromes (1999), 2011-06, Vol.57 (2), p.126-135 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

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Título:
Previous Antiretroviral Therapy for Prevention of Mother-to-Child Transmission of HIV Does not Hamper the Initial Response to PI-Based Multitherapy During Subsequent Pregnancy
Autor: Briand, Nelly ; Mandelbrot, Laurent ; Blanche, Stéphane ; Tubiana, Roland ; Faye, Albert ; Dollfus, Catherine ; Le Chenadec, Jérôme ; Benhammou, Valérie ; Rouzioux, Christine ; Warszawski, Josiane
Assuntos: Adult ; AIDS/HIV ; Anti-HIV Agents - administration & dosage ; Anti-HIV Agents - therapeutic use ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; CD4 Lymphocyte Count ; Drug Therapy, Combination ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; HIV Infections - prevention & control ; HIV Infections - transmission ; Human viral diseases ; Humans ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious diseases ; Medical sciences ; Microbiology ; Miscellaneous ; Pregnancy ; Protease Inhibitors - administration & dosage ; Protease Inhibitors - therapeutic use ; Viral diseases ; Virology ; Young Adult
É parte de: Journal of acquired immune deficiency syndromes (1999), 2011-06, Vol.57 (2), p.126-135
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: BACKGROUND:Few data are available on the possible long-term negative effects of a short exposure to antiretroviral therapy (ART) for prevention of mother-to-child transmission (PMTCT). OBJECTIVE:To determine whether ART for PMTCT, discontinued after delivery, affects the virological response to highly active antiretroviral therapy (HAART) administered during subsequent pregnancies. METHODS:All current pregnancies of HIV-1-infected women enrolled in the French Perinatal Cohort (ANRS CO-01 EPF) between 2005 and 2009 and not receiving ART at the time of conception were eligible. We studied the association between history of exposure to ART during a previous pregnancy and detectable viral load (VL) under multitherapy at current delivery (VL ≥ 50 copies/mL). RESULTS:Among 1116 eligible women, 869 were ART naive and 247 had received PMTCT during a previous pregnancy. Previous ART was protease inhibitor (PI)-based HAART in 48%, non-PI-based HAART in 4%, nucleoside reverse transcriptase inhibitor bitherapy in 19% and zidovudine monotherapy in 29% of the women. At current pregnancy, women with or without prior exposure to ART had similar CD4 cell counts and VL before ART initiation. PI-based HAART was initiated in 90% of the women. VL was undetectable (<50 copies/mL) at delivery in 65% of previously ART-naive women, 72% of women previously exposed to HAART, 62% previously exposed to bitherapy, and 67% previously exposed to monotherapy for prophylaxis (P = 0.42). Detectable VL was not associated with previous exposure in multivariate analysis (adjusted OR for previous versus no previous exposure to ART0.92; 0.95% confidence interval0.59 to 1.44). CONCLUSIONS:Efficacy of PI-based combinations is not decreased in women previously exposed to various regimens of antiretroviral PMTCT.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins, Inc
Idioma: Inglês

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Previous Antiretroviral Therapy for Prevention of Mother-to-Child Transmission of HIV Does not Hamper the Initial Response to PI-Based Multitherapy During Subsequent Pregnancy

Briand, Nelly ; Mandelbrot, Laurent ; Blanche, Stéphane ; Tubiana, Roland ; Faye, Albert ; Dollfus, Catherine ; Le Chenadec, Jérôme ; Benhammou, Valérie ; Rouzioux, Christine ; Warszawski, Josiane

Hagerstown, MD: Lippincott Williams & Wilkins, Inc

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