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Increased Activities of Cardiac Matrix Metalloproteinases Matrix Metalloproteinase (MMP)-2 and MMP-9 Are Associated with Mortality during the Acute Phase of Experimental Trypanosoma cruzi Infection

Gutierrez, Fredy Roberto Salazar ; Lalu, Manoj Mathew ; Mariano, Flávia Sammartino ; Milanezi, Cristiane Maria ; Jonathan, Cena ; Gerlach, Raquel Fernanda ; Santos, Jose Eduardo Tanus ; Diego, Torres-Dueñas ; Cunha, Fernando Queiróz ; Richard, Schulz ; Silva, João Santana

The Journal of infectious diseases, 2008-05, Vol.197 (10), p.1468-1476 [Periódico revisado por pares]

Chicago, IL: The University of Chicago Press

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Título:
Increased Activities of Cardiac Matrix Metalloproteinases Matrix Metalloproteinase (MMP)-2 and MMP-9 Are Associated with Mortality during the Acute Phase of Experimental Trypanosoma cruzi Infection
Autor: Gutierrez, Fredy Roberto Salazar ; Lalu, Manoj Mathew ; Mariano, Flávia Sammartino ; Milanezi, Cristiane Maria ; Jonathan, Cena ; Gerlach, Raquel Fernanda ; Santos, Jose Eduardo Tanus ; Diego, Torres-Dueñas ; Cunha, Fernando Queiróz ; Richard, Schulz ; Silva, João Santana
Assuntos: Animals ; Biological and medical sciences ; Cardiomyopathies ; Chagas Disease - mortality ; Chagas Disease - pathology ; Cytokines ; Cytokines - biosynthesis ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Heart ; Human protozoal diseases ; Infections ; Infectious diseases ; Inflammation ; Matrix Metalloproteinase 2 - genetics ; Matrix Metalloproteinase 2 - metabolism ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase 9 - metabolism ; Medical sciences ; Messenger RNA ; Mice ; Mice, Inbred C57BL ; Microbiology ; Myocarditis ; Myocardium - pathology ; Nitrates - blood ; Nitrites - blood ; Parasitemia ; Parasites ; Parasitic diseases ; Polymerase chain reaction ; Protozoal diseases ; Reverse Transcriptase Polymerase Chain Reaction - methods ; Survival Analysis ; Time Factors ; Trypanosoma cruzi ; Trypanosoma cruzi - physiology ; Trypanosomiasis
É parte de: The Journal of infectious diseases, 2008-05, Vol.197 (10), p.1468-1476
Notas: ark:/67375/HXZ-NK1PDMWG-G
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SourceType-Scholarly Journals-1
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Descrição: The strong inflammatory reaction that occurs in the heart during the acute phase of Trypanosoma cruzi infection is modulated by cytokines and chemokines produced by leukocytes and cardiomyocytes. Matrix metalloproteinases (MMPs) have recently emerged as modulators of cardiovascular inflammation. In the present study we investigated the role of MMP-2 and MMP-9 in T. cruzi-induced myocarditis, by use of immunohistochemical analysis, gelatin zymography, enzyme-linked immunosorbent assay, and real-time polymerase chain reaction to analyze the cardiac tissues of T. cruzi-infected C57BL/6 mice. Increased transcripts levels, immunoreactivity, and enzymatic activity for MMP-2 and MMP-9 were observed by day 14 after infection. Mice treated with an MMP inhibitor showed significantly decreased heart inflammation, delayed peak in parasitemia, and improved survival rates, compared with the control group. Reduced levels of cardiac tumor necrosis factor-α, interferon-γ, serum nitrite, and serum nitrate were also observed in the treated group. These results suggest an important role for MMPs in the induction of T. cruzi-induced acute myocarditis.
Editor: Chicago, IL: The University of Chicago Press
Idioma: Inglês

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Increased Activities of Cardiac Matrix Metalloproteinases Matrix Metalloproteinase (MMP)-2 and MMP-9 Are Associated with Mortality during the Acute Phase of Experimental Trypanosoma cruzi Infection

Gutierrez, Fredy Roberto Salazar ; Lalu, Manoj Mathew ; Mariano, Flávia Sammartino ; Milanezi, Cristiane Maria ; Jonathan, Cena ; Gerlach, Raquel Fernanda ; Santos, Jose Eduardo Tanus ; Diego, Torres-Dueñas ; Cunha, Fernando Queiróz ; Richard, Schulz ; Silva, João Santana

Chicago, IL: The University of Chicago Press

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