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Clinical factors leading to lamotrigine prescription in bipolar outpatients: Subanalysis of the SIN-DEPRES study

Grande, I ; Balanzá-Martínez, V ; Jiménez-Arriero, MA ; Iglesias Lorenzo, F.G ; Franch Valverde, J.I ; de Arce, R ; Zaragoza, S ; Cobaleda, S ; Vieta, E

Journal of affective disorders, 2012-12, Vol.143 (1), p.102-108 [Periódico revisado por pares]

Oxford: Elsevier B.V

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Título:
Clinical factors leading to lamotrigine prescription in bipolar outpatients: Subanalysis of the SIN-DEPRES study
Autor: Grande, I ; Balanzá-Martínez, V ; Jiménez-Arriero, MA ; Iglesias Lorenzo, F.G ; Franch Valverde, J.I ; de Arce, R ; Zaragoza, S ; Cobaleda, S ; Vieta, E
Assuntos: Adult ; Adult and adolescent clinical studies ; Affective disorders ; Aged ; Antimanic Agents - therapeutic use ; Biological and medical sciences ; Bipolar affective disorder ; Bipolar disorder ; Bipolar Disorder - drug therapy ; Bipolar Disorder - psychology ; Bipolar disorders ; Clinical practice ; Clinical predictors ; Community mental health services ; Cross-sectional studies ; Data processing ; Depression ; Depressive Disorder - drug therapy ; Depressive Disorder - psychology ; Drugs ; Female ; Guideline Adherence ; Humans ; Impressions ; Lamotrigine ; Male ; Medical sciences ; Middle Aged ; Mood disorders ; Outpatients ; Polarity ; Prescriptions ; Prospective Studies ; Psychiatric Status Rating Scales ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychotropic drugs ; Regression Analysis ; Triazines - therapeutic use
É parte de: Journal of affective disorders, 2012-12, Vol.143 (1), p.102-108
Notas: ObjectType-Article-2
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Descrição: Abstract Background The use of lamotrigine is a point of discrepancy among the diverse guidelines published on the management of bipolar disorder (BD). Evidence supporting the long-term efficacy is reasonably robust. Nonetheless, the effectiveness of lamotrigine in acute treatment is vigorously debated and it is unclear how this drug is used in routine clinical practice. This subanalysis of the SIN-DEPRES study was designed to understand the clinical profile of bipolar patients receiving lamotrigine. Methods In this prospective national multicenter study, 652 patients with clinically stable bipolar I and II disorder were recruited. Clinical assessments included sociodemographic and clinical data, the Modified Clinical Global Impression scale for BD (CGI-BP-M), the Hamilton Depression Rating Scale (HDRS), and prescriptions of psychotropic medications and their doses. Results By means of a logistic regression model, an association between receiving treatment with lamotrigine and the following clinical variables was found: number of past depressive episodes ( O.R. =2.875, 95% CI: 1.203–6.869, p =0.018), depressive polarity of the most recent episode ( O.R. =1.945, 95% CI: 1.267–2.985, p =0.002), severity in CGI-BD-M depression ( O.R. =1.850, 95% CI: 1.215−2.817, p =0.004), bipolar II disorder diagnosis ( O.R. =1.635, 95% CI: 1.078–2.482, p =0.021) and number of episodes per year ( O.R. =1.310, 95% CI: 1.069–1.605, p =0.009). Limitations Subanalysis of the SIN-DEPRES study with a cross-sectional design. Conclusions The use of lamotrigine in clinical practice is in accordance with most of the guidelines, which support its use in patients with depressive predominant polarity and bipolar II disorder.
Editor: Oxford: Elsevier B.V
Idioma: Inglês

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Clinical factors leading to lamotrigine prescription in bipolar outpatients: Subanalysis of the SIN-DEPRES study

Grande, I ; Balanzá-Martínez, V ; Jiménez-Arriero, MA ; Iglesias Lorenzo, F.G ; Franch Valverde, J.I ; de Arce, R ; Zaragoza, S ; Cobaleda, S ; Vieta, E

Oxford: Elsevier B.V

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