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Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study

Nordestgaard, A. T. ; Stender, S. ; Nordestgaard, B. G. ; Tybjærg‐Hansen, A.

Journal of internal medicine, 2020-01, Vol.287 (1), p.42-53 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Coffee intake protects against symptomatic gallstone disease in the general population: a Mendelian randomization study
  • Autor: Nordestgaard, A. T. ; Stender, S. ; Nordestgaard, B. G. ; Tybjærg‐Hansen, A.
  • Assuntos: Alleles ; Caffeine ; Calculi ; Coffee ; Confidence intervals ; Continuity (mathematics) ; Cytochrome P450 ; Gallstones ; Genetic analysis ; Genetic diversity ; Genetic variance ; Health risk assessment ; Health risks ; Population studies ; Randomization ; Risk
  • É parte de: Journal of internal medicine, 2020-01, Vol.287 (1), p.42-53
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Undefined-1
    ObjectType-Feature-3
    content type line 23
  • Descrição: Background and objectives Coffee intake is associated with low risk of symptomatic gallstone disease (GSD). We tested the hypothesis that high coffee intake causally protects against symptomatic GSD using a Mendelian randomization design. Methods First, we tested whether high coffee intake was associated with low risk of GSD in 104 493 individuals from the general population. Mean follow‐up was 8 years (range: <1–13 years). Secondly, we tested whether two genetic variants near CYP1A1/A2 (rs2472297) and AHR (rs4410790), combined as an allele score, were associated with higher coffee intake measured as a continuous variable. Thirdly, we tested whether the allele score was associated with lower risk of GSD in 114 220 individuals including 7294 gallstone events. Mean follow‐up was 38 years (range: <1–40 years). Results In observational analysis, those with coffee intake of >6 cups daily had 23% lower risk of GSD compared to individuals without coffee intake [hazard ratio (HR) = 0.77 (95% confidence interval: 0.61–0.94)]. In genetic analysis, there was a stepwise higher coffee intake of up to 41% (caffeine per day) in individuals with 4 (highest) versus 0 (lowest) coffee intake alleles (P for trend = 3 x 10−178) and a corresponding stepwise lower risk of GSD up to 19%[HR = 0.81 (0.69–0.96)]. The estimated observational odds ratio for GSD for a one cup per day higher coffee intake was 0.97 (0.96–0.98), equal to 3% lower risk. The corresponding genetic odds ratio was 0.89 (0.83–0.95), equal to 11% lower risk. Conclusion High coffee intake is associated observationally with low risk of GSD, and with genetic evidence to support a causal relationship.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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