Idioma:

A Major Wheat Allergen Has a Gln-Gln-Gln-Pro-Pro Motif Identified as an IgE-Binding Epitope

Tanabe, Soichi ; Arai, Soichi ; Yanagihara, Yukiyoshi ; Mita, Haruhisa ; Takahashi, Kazuo ; Watanabe, Michiko

Biochemical and biophysical research communications, 1996-02, Vol.219 (2), p.290-293 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
A Major Wheat Allergen Has a Gln-Gln-Gln-Pro-Pro Motif Identified as an IgE-Binding Epitope
Autor: Tanabe, Soichi ; Arai, Soichi ; Yanagihara, Yukiyoshi ; Mita, Haruhisa ; Takahashi, Kazuo ; Watanabe, Michiko
Assuntos: alergenos ; allergene ; allergens ; Allergens - chemistry ; Allergens - immunology ; Amino Acid Sequence ; antigene ; antigenos ; antigens ; Basophils - immunology ; Binding Sites, Antibody ; ble ; chemical composition ; composicion quimica ; composition chimique ; Dermatitis, Atopic - blood ; Dermatitis, Atopic - immunology ; Enzyme-Linked Immunosorbent Assay ; Epitopes - chemistry ; Epitopes - immunology ; gluten ; Histamine Release ; Humans ; Immunoglobulin E - blood ; immunoglobuline ; immunoglobulins ; inmunoglobulina ; Molecular Sequence Data ; Oligopeptides - chemical synthesis ; Oligopeptides - immunology ; trigo ; Triticum - immunology ; wheats
É parte de: Biochemical and biophysical research communications, 1996-02, Vol.219 (2), p.290-293
Notas: T
T10
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: The minimum primary structure of the IgE-binding epitope in wheat gluten was determined as Gln-Gln-Gln-Pro-Pro. The N-terminal glutamine and the two proline residues were essential for epitopic function. The occurrence of the second glutamine residue and acetylation of the N-terminal amino group were found to exert some auxiliary functions, whereas only a lesser contribution was expected for the third glutamine residue. It was also been confirmed that acetyl-Gln-Gln-Gln-Pro-Pro bound to wheat-specific IgE antibodies in the sera of patients allergic to wheat, although it did not induce histamine release from the basophils of these patients. Taken together, we concluded that the Gln-Gln-Gln-Pro-Pro motif constituted an IgE-binding rather than immunogenic epitope and also that acetyl-Gln-Gln-Gln-Pro-Pro might act as a hapten capable of binding to specific IgE molecules. The possibility exists that this peptide will have practical application to therapy for or prevention of wheat-sensitive allergy.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 2 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

A Major Wheat Allergen Has a Gln-Gln-Gln-Pro-Pro Motif Identified as an IgE-Binding Epitope

Tanabe, Soichi ; Arai, Soichi ; Yanagihara, Yukiyoshi ; Mita, Haruhisa ; Takahashi, Kazuo ; Watanabe, Michiko

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.