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Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

Brown, Thomas A. D. ; Hogstrom, Kenneth R. ; Alvarez, Diane ; Matthews, Kenneth L. ; Ham, Kyungmin ; Dugas, Joseph P.

Medical physics (Lancaster), 2012-12, Vol.39 (12), p.7412-7417 [Periódico revisado por pares]

United States: American Association of Physicists in Medicine

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Título:
Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams
Autor: Brown, Thomas A. D. ; Hogstrom, Kenneth R. ; Alvarez, Diane ; Matthews, Kenneth L. ; Ham, Kyungmin ; Dugas, Joseph P.
Assuntos: 60 APPLIED LIFE SCIENCES ; Auger electron spectra ; AUGER ELECTRON SPECTROSCOPY ; BRACHYTHERAPY ; CALIBRATION ; Computed tomography ; Computerised tomographs ; computerised tomography ; COMPUTERIZED TOMOGRAPHY ; DEPTH DOSE DISTRIBUTIONS ; Devices sensitive to very short wavelength, e.g. x‐rays, gamma‐rays or corpuscular radiation ; diagnostic radiography ; Dose-Response Relationship, Radiation ; DOSEMETERS ; Dose‐volume analysis ; dosimeters ; DOSIMETRY ; EBT2 ; EBT3 ; ENERGY DEPENDENCE ; Equipment Design ; Equipment Failure Analysis ; Film Dosimetry - instrumentation ; Image scanners ; INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY ; Ionization ; IONIZATION CHAMBERS ; KEV RANGE 10-100 ; MONOCHROMATIC RADIATION ; monochromatic x‐rays ; NEOPLASMS ; PHANTOMS ; Photons ; Radiation Dosage ; RADIATION DOSES ; Radiation therapy ; radiochromic film ; Radiography ; Reproducibility of Results ; Ring currents ; SENSITIVITY ; Sensitivity and Specificity ; SYNCHROTRON RADIATION ; Synchrotrons ; Thin film structure ; Transforming x‐rays ; X RADIATION ; X-Rays ; X‐ and γ‐ray instruments ; X‐ray monochromators ; X‐ray optics ; X‐ray technique
É parte de: Medical physics (Lancaster), 2012-12, Vol.39 (12), p.7412-7417
Notas: tbrown@marybird.com
Author to whom correspondence should be addressed. Electronic mail
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Descrição: Purpose: This work investigates the dose-response curves of GAFCHROMIC® EBT, EBT2, and EBT3 radiochromic films using synchrotron-produced monochromatic x-ray beams. EBT2 film is being utilized for dose verification in photoactivated Auger electron therapy at the Louisiana State University Center for Advanced Microstructures and Devices (CAMD) synchrotron facility. Methods: Monochromatic beams of 25, 30, and 35 keV were generated on the tomography beamline at CAMD. Ion chamber depth-dose measurements were used to determine the dose delivered to films irradiated at depths from 0.7 to 8.5 cm in a 10 × 10 × 10-cm3 polymethylmethacrylate phantom. AAPM TG-61 protocol was applied to convert measured ionization into dose. Films were digitized using an Epson 1680 Professional flatbed scanner and analyzed using the net optical density (NOD) derived from the red channel. A dose-response curve was obtained at 35 keV for EBT film, and at 25, 30, and 35 keV for EBT2 and EBT3 films. Calibrations of films for 4 MV x-rays were obtained for comparison using a radiotherapy accelerator at Mary Bird Perkins Cancer Center. Results: The sensitivity (NOD per unit dose) of EBT film at 35 keV relative to that for 4-MV x-rays was 0.73 and 0.76 for doses 50 and 100 cGy, respectively. The sensitivity of EBT2 film at 25, 30, and 35 keV relative to that for 4-MV x-rays varied from 1.09–1.07, 1.23–1.17, and 1.27–1.19 for doses 50–200 cGy, respectively. For EBT3 film the relative sensitivity was within 3% of unity for all three monochromatic x-ray beams. Conclusions: EBT and EBT2 film sensitivity showed strong energy dependence over an energy range of 25 keV–4 MV, although this dependence becomes weaker for larger doses. EBT3 film shows weak energy dependence, indicating that it would be a better dosimeter for kV x-ray beams where beam hardening effects can result in large changes in the effective energy.
Editor: United States: American Association of Physicists in Medicine
Idioma: Inglês

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Dose-response curve of EBT, EBT2, and EBT3 radiochromic films to synchrotron-produced monochromatic x-ray beams

Brown, Thomas A. D. ; Hogstrom, Kenneth R. ; Alvarez, Diane ; Matthews, Kenneth L. ; Ham, Kyungmin ; Dugas, Joseph P.

United States: American Association of Physicists in Medicine

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