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Perchlorate and Thiocyanate Exposure and Thyroid Function in First-Trimester Pregnant Women

Pearce, Elizabeth N ; Lazarus, John H ; Smyth, Peter P. A ; He, Xuemei ; Dall'Amico, Daniela ; Parkes, Arthur B ; Burns, Robert ; Smith, Derek F ; Maina, Aldo ; Bestwick, Jonathan P ; Jooman, Mohammed ; Leung, Angela M ; Braverman, Lewis E

The journal of clinical endocrinology and metabolism, 2010-07, Vol.95 (7), p.3207-3215 [Periódico revisado por pares]

Bethesda, MD: Endocrine Society

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Título:
Perchlorate and Thiocyanate Exposure and Thyroid Function in First-Trimester Pregnant Women
Autor: Pearce, Elizabeth N ; Lazarus, John H ; Smyth, Peter P. A ; He, Xuemei ; Dall'Amico, Daniela ; Parkes, Arthur B ; Burns, Robert ; Smith, Derek F ; Maina, Aldo ; Bestwick, Jonathan P ; Jooman, Mohammed ; Leung, Angela M ; Braverman, Lewis E
Assuntos: Adult ; Autoantibodies - immunology ; Biological and medical sciences ; Chromatography, Ion Exchange ; Cross-Sectional Studies ; Endocrinopathies ; Enzyme-Linked Immunosorbent Assay ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Health Surveys ; Humans ; Immunoassay ; Iodine - urine ; Italy ; Mass Spectrometry ; Maternal Exposure ; Maternal-Fetal Exchange ; Medical sciences ; Perchlorates - toxicity ; Perchlorates - urine ; Pregnancy ; Pregnancy Trimester, First ; Prospective Studies ; Regression Analysis ; Smoking ; Thiocyanates - toxicity ; Thiocyanates - urine ; Thyroid Function Tests ; Thyroid Gland - drug effects ; Thyroid Gland - immunology ; Thyrotropin - blood ; Thyrotropin - immunology ; Thyroxine - blood ; Thyroxine - immunology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Wales
É parte de: The journal of clinical endocrinology and metabolism, 2010-07, Vol.95 (7), p.3207-3215
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Context: Thyroid hormone, requiring adequate maternal iodine intake, is critical for fetal neurodevelopment. Perchlorate decreases thyroidal iodine uptake by competitively inhibiting the sodium/iodide symporter. It is unclear whether environmental perchlorate exposure adversely affects thyroid function in pregnant women. Thiocyanate, derived from foods and cigarette smoke, is a less potent competitive sodium/iodide symporter inhibitor than perchlorate. Objective: Our objective was to determine whether environmental perchlorate and/or thiocyanate exposure is associated with alterations in thyroid function in pregnancy. Design and Setting: We conducted a cross-sectional study at health centers in Cardiff, Wales, and Turin, Italy. Patients: During 2002–2006, 22,000 women at less than 16 wk gestation were enrolled in the Controlled Antenatal Thyroid Screening Study. Subsets of 261 hypothyroid/hypothyroxinemic and 526 euthyroid women from Turin and 374 hypothyroid/hypothyroxinemic and 480 euthyroid women from Cardiff were selected based on availability of stored urine samples and thyroid function data. Main Outcome Measures: Urinary iodine, thiocyanate, and perchlorate and serum TSH, free T4 (FT4), and thyroperoxidase antibody were measured. Results: Urinary iodine was low: median 98 μg/liter in Cardiff and 52 μg/liter in Turin. Urine perchlorate was detectable in all women. The median (range) urinary perchlorate concentration was 5 μg/liter (0.04–168 μg/liter) in Turin and 2 μg/liter (0.02–368 μg/liter) in Cardiff. There were no associations between urine perchlorate concentrations and serum TSH or FT4 in the individual euthyroid or hypothyroid/hypothyroxinemic cohorts. In multivariable linear analyses, log perchlorate was not a predictor of serum FT4 or TSH. Conclusions: Low-level perchlorate exposure is ubiquitous but did not affect thyroid function in this cohort of iodine-deficient pregnant women. Low-level perchlorate exposure was ubiquitous but did not affect thyroid function in a cohort of iodine-deficient pregnant women.
Editor: Bethesda, MD: Endocrine Society
Idioma: Inglês

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Perchlorate and Thiocyanate Exposure and Thyroid Function in First-Trimester Pregnant Women

Pearce, Elizabeth N ; Lazarus, John H ; Smyth, Peter P. A ; He, Xuemei ; Dall'Amico, Daniela ; Parkes, Arthur B ; Burns, Robert ; Smith, Derek F ; Maina, Aldo ; Bestwick, Jonathan P ; Jooman, Mohammed ; Leung, Angela M ; Braverman, Lewis E

Bethesda, MD: Endocrine Society

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