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Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three‐dimensional power Doppler angiography

Raine‐Fenning, N.J. ; Campbell, B.K. ; Kendall, N.R. ; Clewes, J.S. ; Johnson, I.R.

Human reproduction (Oxford), 2004-02, Vol.19 (2), p.330-338 [Periódico revisado por pares]

Oxford: Oxford University Press

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  • Título:
    Quantifying the changes in endometrial vascularity throughout the normal menstrual cycle with three‐dimensional power Doppler angiography
  • Autor: Raine‐Fenning, N.J. ; Campbell, B.K. ; Kendall, N.R. ; Clewes, J.S. ; Johnson, I.R.
  • Assuntos: Adult ; Aging ; Biological and medical sciences ; Embryology: invertebrates and vertebrates. Teratology ; Endometrium - blood supply ; endometrium/menstrual cycle/power Doppler/subendometrial vascularity/three‐dimensional ultrasound ; Estradiol - blood ; Female ; Follicular Phase ; Fundamental and applied biological sciences. Psychology ; Humans ; Luteal Phase ; Menstrual Cycle ; Ovulation ; Parity ; Progesterone - blood ; Ultrasonography, Doppler - methods
  • É parte de: Human reproduction (Oxford), 2004-02, Vol.19 (2), p.330-338
  • Notas: istex:B0F2B0C954FFE536CFB8E12B7D794E2D7A72310B
    ark:/67375/HXZ-XW2ZL3VP-4
    1To whom correspondence should be addressed at: Academic Division of Reproductive Medicine, D Floor, East Block, Queens Medical Centre, Nottingham NG7 2UH, UK. e‐mail: nick.fenning@nottingham.ac.uk
    local:deh056
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
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  • Descrição: BACKGROUND: We used three‐dimensional power Doppler angiography (3D‐PDA) to examine the periodic changes in endometrial and subendometrial vascularity during the normal menstrual cycle in 27 women without obvious menstrual dysfunction or subfertility. METHODS: 3D‐PDA was performed on alternate days from day 3 of the cycle until ovulation and then every 4 days until menses. Virtual organ computer‐aided analysis and shell‐imaging were used to define and to quantify the power Doppler signal within the endometrial and subendometrial regions producing indices of their relative vascularity. RESULTS: Both the endometrial and subendometrial vascularization index (VI) and vascularization flow index (VFI) increased during the proliferative phase, peaking ∼3 days prior to ovulation (P < 0.001) before decreasing to a nadir 5 days post‐ovulation (P < 0.001). Thereafter, both vascular indices gradually increased during the transition from early to mid‐secretory phase. The flow index (FI) showed a similar pattern but with a longer nadir post‐ovulation. Smoking was associated with a significantly lower VI and VFI. The FI was significantly lower in women aged ≥31 years and significantly higher in parous patients. CONCLUSIONS: Endometrial vascularity, as assessed by 3D‐PDA, varies significantly during the menstrual cycle and is characterized by a pre‐ovulatory peak and post‐ovulatory nadir during the peri‐implantation window.
  • Editor: Oxford: Oxford University Press
  • Idioma: Inglês

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