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Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload

Carruth, Eric D. ; McCulloch, Andrew D. ; Omens, Jeffrey H.

Progress in biophysics and molecular biology, 2016-12, Vol.122 (3), p.215-226 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Transmural gradients of myocardial structure and mechanics: Implications for fiber stress and strain in pressure overload
  • Autor: Carruth, Eric D. ; McCulloch, Andrew D. ; Omens, Jeffrey H.
  • Assuntos: Animals ; Cardiac mechanics ; Fiber strain ; Fiber stress ; Heart - physiology ; Humans ; Myocardium - cytology ; Myocyte fiber angle ; Pressure - adverse effects ; Pressure overload hypertrophy ; Stress, Mechanical ; Transmural gradients
  • É parte de: Progress in biophysics and molecular biology, 2016-12, Vol.122 (3), p.215-226
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: Although a truly complete understanding of whole heart activation, contraction, and deformation is well beyond our current reach, a significant amount of effort has been devoted to discovering and understanding the mechanisms by which myocardial structure determines cardiac function to better treat patients with cardiac disease. Several experimental studies have shown that transmural fiber strain is relatively uniform in both diastole and systole, in contrast to predictions from traditional mechanical theory. Similarly, mathematical models have largely predicted uniform fiber stress across the wall. The development of this uniform pattern of fiber stress and strain during filling and ejection is due to heterogeneous transmural distributions of several myocardial structures. This review summarizes these transmural gradients, their contributions to fiber mechanics, and the potential functional effects of their remodeling during pressure overload hypertrophy.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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