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Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria

Wagner, Anna M. ; Eto, Hiromune ; Joseph, Anton ; Kohyama, Shunshi ; Haraszti, Tamás ; Zamora, Ricardo A. ; Vorobii, Mariia ; Giannotti, Marina I. ; Schwille, Petra ; Rodriguez‐Emmenegger, Cesar

Advanced materials (Weinheim), 2022-07, Vol.34 (28), p.e2202364-n/a [Periódico revisado por pares]

Germany: Wiley Subscription Services, Inc

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  • Título:
    Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria
  • Autor: Wagner, Anna M. ; Eto, Hiromune ; Joseph, Anton ; Kohyama, Shunshi ; Haraszti, Tamás ; Zamora, Ricardo A. ; Vorobii, Mariia ; Giannotti, Marina I. ; Schwille, Petra ; Rodriguez‐Emmenegger, Cesar
  • Assuntos: bacterial cell division ; bottom‐up synthetic biology ; Cell division ; dendrimersomes ; dynamic Min patterns ; E coli ; FtsZ assembly ; Materials science ; Membranes ; synthetic cells ; Task complexity ; Tuning
  • É parte de: Advanced materials (Weinheim), 2022-07, Vol.34 (28), p.e2202364-n/a
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The integration of active cell machinery with synthetic building blocks is the bridge toward developing synthetic cells with biological functions and beyond. Self‐replication is one of the most important tasks of living systems, and various complex machineries exist to execute it. In Escherichia coli, a contractile division ring is positioned to mid‐cell by concentration oscillations of self‐organizing proteins (MinCDE), where it severs membrane and cell wall. So far, the reconstitution of any cell division machinery has exclusively been tied to liposomes. Here, the reconstitution of a rudimentary bacterial divisome in fully synthetic bicomponent dendrimersomes is shown. By tuning the membrane composition, the interaction of biological machinery with synthetic membranes can be tailored to reproduce its dynamic behavior. This constitutes an important breakthrough in the assembly of synthetic cells with biological elements, as tuning of membrane–divisome interactions is the key to engineering emergent biological behavior from the bottom‐up. The reconstitution of a rudimentary bacterial divisome in fully synthetic bicomponent dendrimersomes is shown. The interactions between this active cell machinery and the synthetic membrane are tailored by adjusting its composition. Such fine‐tuning enables the reproduction of the natural dynamic behavior in a synthetic system and constitutes an important breakthrough in the assembly of synthetic cells with biological elements.
  • Editor: Germany: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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