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Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner

Nakatani, Akiho ; Li, Xuan ; Miyamoto, Junki ; Igarashi, Miki ; Watanabe, Hitoshi ; Sutou, Asuka ; Watanabe, Keita ; Motoyama, Takayasu ; Tachibana, Nobuhiko ; Kohno, Mitsutaka ; Inoue, Hiroshi ; Kimura, Ikuo

Biochemical and biophysical research communications, 2018-07, Vol.501 (4), p.955-961 [Periódico revisado por pares]

United States: Elsevier Inc

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  • Título:
    Dietary mung bean protein reduces high-fat diet-induced weight gain by modulating host bile acid metabolism in a gut microbiota-dependent manner
  • Autor: Nakatani, Akiho ; Li, Xuan ; Miyamoto, Junki ; Igarashi, Miki ; Watanabe, Hitoshi ; Sutou, Asuka ; Watanabe, Keita ; Motoyama, Takayasu ; Tachibana, Nobuhiko ; Kohno, Mitsutaka ; Inoue, Hiroshi ; Kimura, Ikuo
  • Assuntos: 60 APPLIED LIFE SCIENCES ; ADIPOSE TISSUE ; BILE ACIDS ; Energy metabolism ; GLUCAGON ; GLUCOSE ; Gut microbiota ; High-fat diet ; INSULIN ; LIVER ; METABOLIC DISEASES ; MICE ; Mung bean protein ; Obesity
  • É parte de: Biochemical and biophysical research communications, 2018-07, Vol.501 (4), p.955-961
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The 8-globulin-rich mung bean protein (MPI) suppresses hepatic lipogenesis in rodent models and reduces fasting plasma glucose and insulin levels in obese adults. However, its effects on mitigating high fat diet (HFD)-induced obesity and the mechanism underlying these effects remain to be elucidated. Herein, we examined the metabolic phenotype, intestinal bile acid (BA) pool, and gut microbiota of conventionally raised (CONV-R) male C57BL/6 mice and germ-free (GF) mice that were randomized to receive either regular HFD or HFD containing mung bean protein isolate (MPI) instead of the dairy protein present in regular HFD. MPI intake significantly reduced HFD-induced weight gain and adipose tissue accumulation, and attenuated hepatic steatosis. Enhancement in the secretion of intestinal glucagon-like peptide-1 (GLP-1) and an enlarged cecal and fecal BA pool of dramatically elevated secondary/primary BA ratio were observed in mice that had consumed MPI. These effects were abolished in GF mice, indicating that the effects were dependent upon the presence of the microbiota. As revealed by 16S rRNA gene sequence analysis, MPI intake also elicited dramatic changes in the gut microbiome, such as an expansion of taxa belonging to the phylum Bacteroidetes along with a reduced abundance of the Firmicutes. •Mung bean protein intake reduces high fat diet-induced weight gain, fat accumulation, and hepatic steatosis. .•Mung bean protein intake increases plasma GLP-1 and intestinal secondary bile acids.•The anti-obesity effects occur via a mechanism that depends on the gut microbiota.
  • Editor: United States: Elsevier Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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