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Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects Against Recurrence-Free Survival in Breast Cancer Patients

Maeda, N. ; Yoshimura, K. ; Yamamoto, S. ; Kuramasu, A. ; Inoue, M. ; Suzuki, N. ; Watanabe, Y. ; Maeda, Y. ; Kamei, R. ; Tsunedomi, R. ; Shindo, Y. ; Inui, M. ; Tamada, K. ; Yoshino, S. ; Hazama, S. ; Oka, M.

Annals of surgical oncology, 2014-12, Vol.21 (Suppl 4), p.546-554 [Periódico revisado por pares]

Boston: Springer US

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Título:
Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects Against Recurrence-Free Survival in Breast Cancer Patients
Autor: Maeda, N. ; Yoshimura, K. ; Yamamoto, S. ; Kuramasu, A. ; Inoue, M. ; Suzuki, N. ; Watanabe, Y. ; Maeda, Y. ; Kamei, R. ; Tsunedomi, R. ; Shindo, Y. ; Inui, M. ; Tamada, K. ; Yoshino, S. ; Hazama, S. ; Oka, M.
Assuntos: B7 Antigens - analysis ; Breast Neoplasms - chemistry ; Breast Neoplasms - immunology ; Breast Neoplasms - pathology ; Carcinoma, Ductal, Breast - chemistry ; Carcinoma, Ductal, Breast - immunology ; Carcinoma, Ductal, Breast - pathology ; Disease-Free Survival ; Female ; Forkhead Transcription Factors - analysis ; Humans ; Lymphocyte Count ; Lymphocytes, Tumor-Infiltrating - chemistry ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Receptor, ErbB-2 - analysis ; Surgery ; Surgical Oncology ; Survival Rate ; T-Lymphocytes, Regulatory - chemistry ; Translational Research and Biomarkers ; Tumor Burden ; Tumor Escape ; Tumor Microenvironment - immunology
É parte de: Annals of surgical oncology, 2014-12, Vol.21 (Suppl 4), p.546-554
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Background In the tumor microenvironment, factors inhibiting the targeting of cancer cells by activated T cells have recently been noted. B7-H3 belongs to the B7 superfamily of immune regulatory ligands and plays an important role in the adaptive immune response of co-inhibitory/stimulatory factors in regulating T cells. However, the degree to which B7-H3 directly affects tumor immune evasion mechanisms remains unclear, particularly in patients with breast cancer. Regulatory T cells (Tregs) are known as a key player in the inhibition of immune mechanisms. The present study demonstrated that expression of B7-H3 on tumor cells and the number of Tregs in the tumor microenvironment independently affected prognosis in breast cancer patients. Methods We immunohistochemically investigated the presence of B7-H3 and forkhead box P3 (Foxp3)-positive Tregs in pathological specimens from 90 patients with breast cancer. Results Positive B7-H3 expression was associated with shorter recurrence-free survival (RFS) ( p = 0.014). A higher percentage of Foxp3-positive cells also correlated with shorter RFS ( p = 0.039). Multivariate analysis showed B7-H3 as an independent factor on RFS. Foxp3 expression in tumor-infiltrating lymphocytes (TILs) correlated significantly with larger tumor size (>2 cm), expression of human epidermal growth factor receptor 2 (HER2), and higher nuclear grade ( p = 0.003, p < 0.001, p = 0.001, respectively). No correlation was identified between expression of B7-H3 and the percentage of Foxp3-positive TILs. Conclusions B7-H3 and Foxp3 can be regarded as markers of poor prognosis in breast cancer. These expressions were not correlated, suggesting that B7-H3 expression plays an independent role in tumor immune evasion, regardless of Tregs.
Editor: Boston: Springer US
Idioma: Inglês

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Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects Against Recurrence-Free Survival in Breast Cancer Patients

Maeda, N. ; Yoshimura, K. ; Yamamoto, S. ; Kuramasu, A. ; Inoue, M. ; Suzuki, N. ; Watanabe, Y. ; Maeda, Y. ; Kamei, R. ; Tsunedomi, R. ; Shindo, Y. ; Inui, M. ; Tamada, K. ; Yoshino, S. ; Hazama, S. ; Oka, M.

Boston: Springer US

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