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The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Maloberti, Alessandro ; Mengozzi, Alessandro ; Russo, Elisa ; Cicero, Arrigo Francesco Giuseppe ; Angeli, Fabio ; Agabiti Rosei, Enrico ; Barbagallo, Carlo Maria ; Bernardino, Bruno ; Bombelli, Michele ; Cappelli, Federica ; Casiglia, Edoardo ; Cianci, Rosario ; Ciccarelli, Michele ; Cirillo, Massimo ; Cirillo, Pietro ; Desideri, Giovambattista ; D’Elia, Lanfranco ; Dell’Oro, Raffaella ; Facchetti, Rita ; Ferri, Claudio ; Galletti, Ferruccio ; Giannattasio, Cristina ; Gesualdo, Loreto ; Iaccarino, Guido ; Lippa, Luciano ; Mallamaci, Francesca ; Masi, Stefano ; Masulli, Maria ; Mazza, Alberto ; Muiesan, Maria Lorenza ; Nazzaro, Pietro ; Parati, Gianfranco ; Palatini, Paolo ; Pauletto, Paolo ; Pontremoli, Roberto ; Pugliese, Nicola Riccardo ; Quarti-Trevano, Fosca ; Rattazzi, Marcello ; Reboldi, Gianpaolo ; Rivasi, Giulia ; Salvetti, Massimo ; Tikhonoff, Valerie ; Tocci, Giuliano ; Ungar, Andrea ; Verdecchia, Paolo ; Viazzi, Francesca ; Volpe, Massimo ; Virdis, Agostino ; Grassi, Guido ; Borghi, Claudio

High Blood Pressure & Cardiovascular Prevention, 2023-09, Vol.30 (5), p.411-425 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation
Autor: Maloberti, Alessandro ; Mengozzi, Alessandro ; Russo, Elisa ; Cicero, Arrigo Francesco Giuseppe ; Angeli, Fabio ; Agabiti Rosei, Enrico ; Barbagallo, Carlo Maria ; Bernardino, Bruno ; Bombelli, Michele ; Cappelli, Federica ; Casiglia, Edoardo ; Cianci, Rosario ; Ciccarelli, Michele ; Cirillo, Massimo ; Cirillo, Pietro ; Desideri, Giovambattista ; D’Elia, Lanfranco ; Dell’Oro, Raffaella ; Facchetti, Rita ; Ferri, Claudio ; Galletti, Ferruccio ; Giannattasio, Cristina ; Gesualdo, Loreto ; Iaccarino, Guido ; Lippa, Luciano ; Mallamaci, Francesca ; Masi, Stefano ; Masulli, Maria ; Mazza, Alberto ; Muiesan, Maria Lorenza ; Nazzaro, Pietro ; Parati, Gianfranco ; Palatini, Paolo ; Pauletto, Paolo ; Pontremoli, Roberto ; Pugliese, Nicola Riccardo ; Quarti-Trevano, Fosca ; Rattazzi, Marcello ; Reboldi, Gianpaolo ; Rivasi, Giulia ; Salvetti, Massimo ; Tikhonoff, Valerie ; Tocci, Giuliano ; Ungar, Andrea ; Verdecchia, Paolo ; Viazzi, Francesca ; Volpe, Massimo ; Virdis, Agostino ; Grassi, Guido ; Borghi, Claudio
Assuntos: Age ; Biomarkers ; Blood pressure ; Cardiology ; Cardiovascular disease ; Confounding (Statistics) ; Diabetes ; Diuretics ; Health risks ; Heart attacks ; Heart failure ; Heart rate ; Hypertension ; Insulin resistance ; Kidney diseases ; Medicine ; Medicine & Public Health ; Metabolic disorders ; Metabolism ; Mortality ; Pharmacotherapy ; Placebo effect ; Population ; Review ; Review Article ; Rheumatism ; Stroke ; Uric acid ; Variables ; Womens health
É parte de: High Blood Pressure & Cardiovascular Prevention, 2023-09, Vol.30 (5), p.411-425
Descrição: The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation

Cham: Springer International Publishing

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