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Digit ratio (2D:4D) in newborns: Influences of prenatal testosterone and maternal environment

Ventura, T ; Gomes, M.C ; Pita, A ; Neto, M.T ; Taylor, A

Early human development, 2013-02, Vol.89 (2), p.107-112 [Periódico revisado por pares]

Amsterdam: Elsevier Ireland Ltd

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  • Título:
    Digit ratio (2D:4D) in newborns: Influences of prenatal testosterone and maternal environment
  • Autor: Ventura, T ; Gomes, M.C ; Pita, A ; Neto, M.T ; Taylor, A
  • Assuntos: 2D:4D ; Adult ; Advanced Basic Science ; Amniotic Fluid - chemistry ; Biological and medical sciences ; Digit ratio ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fingers - anatomy & histology ; Functional Laterality ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant, Newborn ; Male ; Neonatal and Perinatal Medicine ; Newborn ; Sex Characteristics ; Sexual dimorphism ; Testosterone ; Testosterone - analysis ; Testosterone - blood
  • É parte de: Early human development, 2013-02, Vol.89 (2), p.107-112
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: Abstract Introduction The 2D:4D digit ratio is sexually-dimorphic, probably due to testosterone action through the perinatal period. We characterize the 2D:4D ratio in newborn (NB) infants, in between the pre- and postnatal surges of testosterone, and relate it to the mother's 2D:4D and to testosterone levels in the amniotic fluid (AF). Subjects and methods Testosterone was assayed in samples of maternal plasma and AF collected at amniocentesis. Shortly after birth, 106 NBs and their mothers were measured for 2D:4D ratio. Results NB males had lower mean 2D:4D ratios than females but this dimorphism was significant only for the left hand (males: 0.927; females: 0.950; p = 0.004). Mothers who had sons had lower 2D:4D ratios than those who had daughters and the mother's 2D:4D were higher than those of NBs regardless of sex. Both hands of NB females were negatively correlated with AF testosterone and positively correlated with the mother's 2D:4D, but males showed no significant associations. Maternal plasma testosterone also showed a negative weak correlation with NB's digit ratio in both sexes. Conclusions Sexual dimorphism at birth was only significant for the left hand, in contrast with reports of greater right hand dimorphism, suggesting that postnatal testosterone is determinant for 2D:4D stabilization. The lower 2D:4D ratios in mothers who had sons support claims that hormone levels in parents are influential for determining their children's sex. NB female's digit ratio, but not males', was associated to the level of AF testosterone. The mother's 2D:4D ratios were positively correlated with their daughters' 2D:4D, but the same was not observed for male NBs, suggesting that prenatal testosterone levels in male fetus lead their 2D:4D ratios to stray from their mothers' with high individual variability.
  • Editor: Amsterdam: Elsevier Ireland Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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