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B-1 cells participate in 1-DAY BCG-induced pulmonary lesions in mice

R T Russo J D Lopes; Mario Mariano; Meeting of the Brazilian Society for Immunology (31. 2006 Búzios)

Abstracts São Paulo, SP: Brazilian Society for Immunology, 2006

São Paulo 2006

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  • Título:
    B-1 cells participate in 1-DAY BCG-induced pulmonary lesions in mice
  • Autor: R T Russo
  • J D Lopes; Mario Mariano; Meeting of the Brazilian Society for Immunology (31. 2006 Búzios)
  • Assuntos: IMUNOLOGIA
  • É parte de: Abstracts São Paulo, SP: Brazilian Society for Immunology, 2006
  • Notas: Disponível em CD-ROM
  • Descrição: Introduction and Objective: It has been established in our laboratory that B-1 cells that reside in peritoneal and pleural cavities proliferate in culture of adherent peritoneal cells. It has also been demonstrated that B-1 cells migrate to an acute inflammatory milieu and differentiate into macrophage-like mononuclear phagocytes, provisionally called "lymphophage". These data led us to investigate the possible participation of these cells in Mycobacterium bovis bacillus Calmette-Guerin-induced granulomatous inflammation. Methods and Results: To approach this issue, we assessed the presence of B-1 cells in bronchoalveolar lavage (BAL) from three groups of 5 BALB/c mice: the first group was intratracheally infected with BCG (106 CFU in 50 L / animal), the second group was intratracheally injected with PBS, and the third group was not infected. BALs were taken in pools, within 1 day after infection with BCG. BALs from PBS inoculated and non-injected mice did not contain B-1 cells. Conversely, a small - yet clear - proportion of IgM+CD5+CD11b+F4/80+ cells (B-1 cells) were characterized in the BAL from BCGinfected mice. Conclusion: These preliminary results demonstrate that B-1 cells migrate to BCG-induced pulmonary lesions within only 1 day post-infection.
  • Editor: São Paulo
  • Data de criação/publicação: 2006
  • Formato: res. CI.034.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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