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Value of the oxygen pulse curve for the diagnosis of coronary artery disease

De Lorenzo, A ; Da Silva, C L ; Castro Souza, F C ; De Souza Leao Lima, R

Physiological research, 2018-01, Vol.67 (5), p.679-686 [Periódico revisado por pares]

Czech Republic: Institute of Physiology

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Título:
Value of the oxygen pulse curve for the diagnosis of coronary artery disease
Autor: De Lorenzo, A ; Da Silva, C L ; Castro Souza, F C ; De Souza Leao Lima, R
Assuntos: Aged ; Anemia ; Cardiovascular disease ; Coronary artery ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - metabolism ; Coronary Artery Disease - physiopathology ; Coronary vessels ; Councils ; Diagnosis ; Electrocardiography ; Exercise Test - methods ; Exercise Test - standards ; Female ; Gases ; Heart diseases ; Heart failure ; Heart rate ; Humans ; Hypertension ; Ischemia ; Male ; Medical diagnosis ; Medical imaging ; Middle Aged ; Myocardial ischemia ; Myocardial Perfusion Imaging - methods ; Myocardial Perfusion Imaging - standards ; Oxygen ; Oxygen Consumption - physiology ; Perfusion ; Physiology ; Scintigraphy ; Stroke
É parte de: Physiological research, 2018-01, Vol.67 (5), p.679-686
Descrição: This study investigated the value of oxygen (O(2)) pulse curves obtained during cardiopulmonary exercise testing (CPET) for the diagnosis of coronary artery disease (CAD). Forty patients with known coronary anatomy (35.0 % normal, 27.0 % single-vessel and 38.0 % multivessel CAD) underwent CPET with radiotracer injection at peak exercise, followed by myocardial scintigraphy. O(2) pulse curves were classified as: A-normal, B-probably normal (normal slope with low peak value); C-probably abnormal (flat, with low peak value); or D-definitely abnormal (descending slope). Sensitivity, specificity, positive and negative predictive values of the O(2) pulse curve pattern (A or B vs. C or D) for the diagnosis of CAD were, respectively, 38.5 %, 81.3 %, 76.9 %, and 44.8 %. The concordance rate between the abnormal O(2) pulse curve pattern and ischemia in myocardial scintigraphy was 38.1 %. Age and the extent of scintigraphic perfusion defect, but not the abnormal O(2) pulse curve patterns (B or C or both combined) were independently associated with CAD. In conclusion, the O(2) pulse curve pattern has low diagnostic performance for the diagnosis of obstructive CAD, and the abnormal curve pattern was not associated with myocardial ischemia defined by scintigraphy.
Editor: Czech Republic: Institute of Physiology
Idioma: Inglês

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Value of the oxygen pulse curve for the diagnosis of coronary artery disease

De Lorenzo, A ; Da Silva, C L ; Castro Souza, F C ; De Souza Leao Lima, R

Czech Republic: Institute of Physiology

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