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Impact of tube current in the quantitative assessment of acute reperfused myocardial infarction with 64-slice delayed-enhancement CT: a porcine model

Martini, C. ; Maffei, E. ; Palumbo, A. ; Weustink, A. ; Baks, T. ; Moelker, A. ; Dunker, D. ; Cuttone, A. ; Emiliano, E. ; Mollet, N. ; Krestin, G. ; De Feyter, P. ; Cademartiri, F.

Radiologia medica, 2010-10, Vol.115 (7), p.1003-1014 [Revista revisada por pares]

Milan: Springer Milan

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Título:
Impact of tube current in the quantitative assessment of acute reperfused myocardial infarction with 64-slice delayed-enhancement CT: a porcine model
Autor: Martini, C. ; Maffei, E. ; Palumbo, A. ; Weustink, A. ; Baks, T. ; Moelker, A. ; Dunker, D. ; Cuttone, A. ; Emiliano, E. ; Mollet, N. ; Krestin, G. ; De Feyter, P. ; Cademartiri, F.
Materias: Animals ; Cardiac Radiology/Cardioradiologia ; Contrast Media ; Coronary Angiography ; Coronary Circulation ; Diagnostic Radiology ; Heart - diagnostic imaging ; Imaging ; Interventional Radiology ; Medicine ; Medicine & Public Health ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - physiopathology ; Myocardial Infarction - therapy ; Myocardial Reperfusion ; Neuroradiology ; Radiology ; Sus scrofa ; Tomography, X-Ray Computed - methods ; Ultrasound
Es parte de: Radiologia medica, 2010-10, Vol.115 (7), p.1003-1014
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Purpose This study evaluated the impact of tube current (mAs) in delayed-enhancement computed tomography (CT) imaging for assessing acute reperfused myocardial infarction in a porcine model. Materials and methods In five domestic pigs (mean weight 24 kg), the circumflex coronary artery was balloon-occluded for 2 h and then reperfused. After 5 days, CT imaging was performed following administration of iodinated contrast material. A 64-slice CT system was used to perform first-pass coronary angiography with a tube current of 15 mAs/kg [Arterial Phase (ART)] followed by two delayed-enhancement (DE) scans 15 min after contrast material administration, with a tube current of 15 mAs/kg and 37.5 mAs/kg, respectively (DE 1 and DE 2 ). The mean heart rate decreased to 51±9 beats/min after administration of zatebradine (10 mg/kg IV). The data set was reconstructed during the end-diastolic phase of the cardiac cycle. Areas with DE, no reflow and remote myocardium [remote left ventricular (LV)] were calculated. CT values expressed in Hounsfield units (HU) were measured using five regions of interest (ROI): DE, no reflow, remote LV, LV cavity (LV lumen) and in air, respectively. Differences, correlations, image quality [signal-to-noise ratio (SNR)] and contrast resolution [contrast-to-noise ratio (CNR)] were calculated. Results Significant differences were found between attenuation of areas of DE, no reflow and remote LV ( p <0.001) within the different scans. There was a fair correlation between DE and no-reflow attenuation ( r =0.6; p <0.001). In DE 1 vs. DE 2 , areas of DE and no reflow were not significantly different ( p >0.05). The SNR and CNR were not significantly different in DE 1 vs. DE 2 ( p >0.05). Conclusions Tube current does not significantly affect infarction area, image quality or contrast resolution of DE imaging with CT.
Editor: Milan: Springer Milan
Idioma: Inglés;Italiano

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Impact of tube current in the quantitative assessment of acute reperfused myocardial infarction with 64-slice delayed-enhancement CT: a porcine model

Martini, C. ; Maffei, E. ; Palumbo, A. ; Weustink, A. ; Baks, T. ; Moelker, A. ; Dunker, D. ; Cuttone, A. ; Emiliano, E. ; Mollet, N. ; Krestin, G. ; De Feyter, P. ; Cademartiri, F.

Milan: Springer Milan

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