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Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers

Caram, Laura Miranda de Oliveira ; Ferrari, R ; Nogueira, D L ; Oliveira, Mrm ; Francisqueti, F V ; Tanni, S E ; Corrêa, C R ; Godoy, I

International journal of chronic obstructive pulmonary disease, 2017-01, Vol.12, p.2015-2021 [Periódico revisado por pares]

New Zealand: Dove Medical Press Limited

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Título:
Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers
Autor: Caram, Laura Miranda de Oliveira ; Ferrari, R ; Nogueira, D L ; Oliveira, Mrm ; Francisqueti, F V ; Tanni, S E ; Corrêa, C R ; Godoy, I
Assuntos: Aged ; Airway management ; Asymptomatic ; Asymptomatic Diseases ; Biological markers ; Biomarkers - blood ; Body composition ; Body mass index ; C-Reactive Protein - analysis ; Case-Control Studies ; Chronic obstructive lung disease ; Chronic obstructive pulmonary disease ; Cross-Sectional Studies ; Dyspnea ; Female ; Glycation End Products, Advanced - blood ; Health aspects ; Humans ; Inflammation ; inflammation mediators ; Inflammation Mediators - blood ; Interleukin-6 - blood ; Lung diseases, Obstructive ; Male ; Middle Aged ; Original Research ; Oxidative Stress ; Proteins ; Pulmonary Disease, Chronic Obstructive - blood ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - etiology ; Pulse oximetry ; Receptor for Advanced Glycation End Products - blood ; Receptors, Tumor Necrosis Factor, Type I - blood ; Receptors, Tumor Necrosis Factor, Type II - blood ; Regression analysis ; Signal transduction ; Smokers ; Smoking ; Smoking - adverse effects ; Smoking - blood ; Smoking Cessation ; Spirometry ; Tumor necrosis factor ; Tumor necrosis factor-TNF ; Up-Regulation ; Values ; Variables ; Variance analysis
É parte de: International journal of chronic obstructive pulmonary disease, 2017-01, Vol.12, p.2015-2021
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Oxidative stress and systemic inflammation are higher in smokers and patients with COPD; however, markers that may help differentiate between smokers and patients with COPD have not yet been identified. We hypothesized that tumor necrosis factor-alpha receptor (TNFR) and soluble form of the receptor for advanced glycation end products (sRAGE) can be indicators of COPD in asymptomatic patients. We evaluated 32 smokers (smoking history >10 pack-years), 32 patients with mild/moderate COPD (smokers and ex-smokers), and 32 never smokers. Concentrations of C-reactive protein (CRP), interleukin (IL)-6, TNFR1 and TNFR2, advanced glycation end products (AGEs), and the sRAGE were measured in serum. There were higher CRP and AGEs concentrations in smokers and in patients with COPD ( <0.001 and =0.01, respectively) compared to controls, without statistical difference between smokers and patients with COPD. Concentrations of sRAGE, IL-6, and TNFR1 did not differ between study groups. TNFR2 was significantly higher in patients with COPD than in smokers ( =0.004) and controls ( =0.004), and the presence of COPD ( =0.02) and CRP ( =0.001) showed a positive association with TNFR2. Positive associations for smoking ( =0.04), CRP ( =0.03), and IL-6 ( =0.03) with AGEs were also found. The interaction variable (smoking × COPD) showed a positive association with IL-6. Our data suggest that TNFR2 may be a possible marker of COPD in asymptomatic smokers and ex-smokers. Although smokers and patients with early COPD presented other increased systemic inflammation markers (eg, CRP) and oxidative stress (measured by AGEs), they did not differentiate smokers from COPD.
Editor: New Zealand: Dove Medical Press Limited
Idioma: Inglês

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Tumor necrosis factor receptor 2 as a possible marker of COPD in smokers and ex-smokers

Caram, Laura Miranda de Oliveira ; Ferrari, R ; Nogueira, D L ; Oliveira, Mrm ; Francisqueti, F V ; Tanni, S E ; Corrêa, C R ; Godoy, I

New Zealand: Dove Medical Press Limited

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