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Diffusion tensor and restriction spectrum imaging reflect different aspects of neurodegeneration in Parkinson's disease

Hope, Tuva R ; Selnes, Per ; Rektorová, Irena ; Anderkova, Lubomira ; Nemcova-Elfmarkova, Nela ; Balážová, Zuzana ; Dale, Anders ; Bjørnerud, Atle ; Fladby, Tormod Yap, Pew-Thian

PloS one, 2019, Vol.14 (5), p.e0217922-e0217922 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Diffusion tensor and restriction spectrum imaging reflect different aspects of neurodegeneration in Parkinson's disease
Autor: Hope, Tuva R ; Selnes, Per ; Rektorová, Irena ; Anderkova, Lubomira ; Nemcova-Elfmarkova, Nela ; Balážová, Zuzana ; Dale, Anders ; Bjørnerud, Atle ; Fladby, Tormod
Yap, Pew-Thian
Assuntos: Adult ; Aged ; Aged, 80 and over ; Alzheimer's disease ; Anisotropy ; Atrophy ; Biology and Life Sciences ; Biomarkers ; Brain ; Brain Stem - diagnostic imaging ; Brain Stem - pathology ; Central nervous system ; Change detection ; Clinical medicine ; Cognition & reasoning ; Dementia ; Diagnostic Imaging ; Diffusion ; Diffusion Magnetic Resonance Imaging ; Diffusion Tensor Imaging ; Diffusivity ; Disease control ; Dopamine ; Female ; Gray Matter - diagnostic imaging ; Gray Matter - pathology ; Hospitals ; Humans ; Magnetic resonance imaging ; Male ; Mathematical analysis ; Medical imaging ; Medicine and Health Sciences ; Microstructure ; Middle Aged ; Multiple sclerosis ; Nerve Degeneration - diagnosis ; Nerve Degeneration - diagnostic imaging ; Nerve Degeneration - pathology ; Neurodegeneration ; Neuroimaging ; Neurology ; Neurosciences ; NMR ; Nuclear magnetic resonance ; Nuclear medicine ; Parkinson Disease - diagnosis ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - pathology ; Parkinson's disease ; Pathology ; Physical Sciences ; Physics ; Research and Analysis Methods ; Substantia grisea ; Substantia Nigra - diagnostic imaging ; Substantia Nigra - pathology ; Tensors ; Thalamus ; Thalamus - diagnostic imaging ; Thalamus - pathology
É parte de: PloS one, 2019, Vol.14 (5), p.e0217922-e0217922
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: To meet the need for Parkinson's disease biomarkers and evidence for amount and distribution of pathological changes, MRI diffusion tensor imaging (DTI) has been explored in a number of previous studies. However, conflicting results warrant further investigations. As tissue microstructure, particularly of the grey matter, is heterogeneous, a more precise diffusion model may benefit tissue characterization. The purpose of this study was to analyze the diffusion-based imaging technique restriction spectrum imaging (RSI) and DTI, and their ability to detect microstructural changes within brain regions associated with motor function in Parkinson's disease. Diffusion weighted (DW) MR images of a total of 100 individuals, (46 Parkinson's disease patients and 54 healthy controls) were collected using b-values of 0-4000s/mm2. Output diffusion-based maps were estimated based on the RSI-model combining the full set of DW-images (Cellular Index (CI), Neurite Density (ND)) and DTI-model combining b = 0 and b = 1000 s/mm2 (fractional anisotropy (FA), Axial-, Mean- and Radial diffusivity (AD, MD, RD)). All parametric maps were analyzed in a voxel-wise group analysis, with focus on typical brain regions associated with Parkinson's disease pathology. CI, ND and DTI diffusivity metrics (AD, MD, RD) demonstrated the ability to differentiate between groups, with strongest performance within the thalamus, prone to pathology in Parkinson's disease. Our results indicate that RSI may improve the predictive power of diffusion-based MRI, and provide additional information when combined with the standard diffusivity measurements. In the absence of major atrophy, diffusion techniques may reveal microstructural pathology. Our results suggest that protocols for MRI diffusion imaging may be adapted to more sensitive detection of pathology at different sites of the central nervous system.
Editor: United States: Public Library of Science
Idioma: Inglês;Norueguês

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Diffusion tensor and restriction spectrum imaging reflect different aspects of neurodegeneration in Parkinson's disease

Hope, Tuva R ; Selnes, Per ; Rektorová, Irena ; Anderkova, Lubomira ; Nemcova-Elfmarkova, Nela ; Balážová, Zuzana ; Dale, Anders ; Bjørnerud, Atle ; Fladby, Tormod Yap, Pew-Thian

United States: Public Library of Science

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