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Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder

Belmonte Mahon, Pamela ; Pirooznia, Mehdi ; Goes, Fernando S. ; Seifuddin, Fayaz ; Steele, Jo ; Lee, Phil Hyoun ; Huang, Jie ; Hamshere, Marian L. ; DePaulo Jr, J. Raymond ; Kelsoe, John R. ; Rietschel, Marcella ; Nöthen, Markus ; Cichon, Sven ; Gurling, Hugh ; Purcell, Shaun ; Smoller, Jordan W. ; Craddock, Nick ; Schulze, Thomas G. ; McMahon, Francis J. ; Potash, James B. ; Zandi, Peter P.

American journal of medical genetics. Part B, Neuropsychiatric genetics, 2011-04, Vol.156B (3), p.370-378 [Periódico revisado por pares]

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Título:
Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder
Autor: Belmonte Mahon, Pamela ; Pirooznia, Mehdi ; Goes, Fernando S. ; Seifuddin, Fayaz ; Steele, Jo ; Lee, Phil Hyoun ; Huang, Jie ; Hamshere, Marian L. ; DePaulo Jr, J. Raymond ; Kelsoe, John R. ; Rietschel, Marcella ; Nöthen, Markus ; Cichon, Sven ; Gurling, Hugh ; Purcell, Shaun ; Smoller, Jordan W. ; Craddock, Nick ; Schulze, Thomas G. ; McMahon, Francis J. ; Potash, James B. ; Zandi, Peter P.
Assuntos: Adult and adolescent clinical studies ; Age ; Age of Onset ; Association analysis ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - complications ; Bipolar Disorder - epidemiology ; Bipolar Disorder - genetics ; Bipolar disorders ; Demography ; Female ; Genetic diversity ; Genome-Wide Association Study ; Genomes ; Germany - epidemiology ; Humans ; Male ; Medical genetics ; Medical sciences ; Miscellaneous ; Mood disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychotic Disorders - complications ; Psychotic Disorders - epidemiology ; Psychotic Disorders - genetics ; Replication ; Reviews ; Single-nucleotide polymorphism ; Young Adult
É parte de: American journal of medical genetics. Part B, Neuropsychiatric genetics, 2011-04, Vol.156B (3), p.370-378
Notas: Pamela Belmonte Mahon and Mehdi Pirooznia contributed equally to this work.
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Please cite this article as follows: Belmonte Mahon P, Pirooznia M, Goes FS, Seifuddin F, Steele J, Lee PH, Huang J, Hamshere M, The Bipolar Genome Study (BiGS) Consortium, The Wellcome Trust Case Control Consortium Bipolar Disorder Group, DePaulo JR Jr, Kelsoe JR, Rietschel M, Nöthen M, Cichon S, Gurling H, Purcell S, Smoller JW, Craddock N, Schulze TG, McMahon FJ, Potash JB, Zandi PP. 2011. Genome-Wide Association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet Part B 156:370-378.
Please cite this article as follows: Belmonte Mahon P, Pirooznia M, Goes FS, Seifuddin F, Steele J, Lee PH, Huang J, Hamshere M, The Bipolar Genome Study (BiGS) Consortium, The Wellcome Trust Case Control Consortium Bipolar Disorder Group, DePaulo JR Jr, Kelsoe JR, Rietschel M, Nöthen M, Cichon S, Gurling H, Purcell S, Smoller JW, Craddock N, Schulze TG, McMahon FJ, Potash JB, Zandi PP. 2011. Genome‐Wide Association analysis of age at onset and psychotic symptoms in bipolar disorder. Am J Med Genet Part B 156:370–378.
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Joint first authors
Descrição: Genome‐wide association studies (GWAS) have identified several susceptibility loci for bipolar disorder (BP), most notably ANK3. However, most of the inherited risk for BP remains unexplained. One reason for the limited success may be the genetic heterogeneity of BP. Clinical sub‐phenotypes of BP may identify more etiologically homogeneous subsets of patients, which can be studied with increased power to detect genetic variation. Here, we report on a mega‐analysis of two widely studied sub‐phenotypes of BP, age at onset and psychotic symptoms, which are familial and clinically significant. We combined data from three GWAS: NIMH Bipolar Disorder Genetic Association Information Network (GAIN‐BP), NIMH Bipolar Disorder Genome Study (BiGS), and a German sample. The combined sample consisted of 2,836 BP cases with information on sub‐phenotypes and 2,744 controls. Imputation was performed, resulting in 2.3 million SNPs available for analysis. No SNP reached genome‐wide significance for either sub‐phenotype. In addition, no SNP reached genome‐wide significance in a meta‐analysis with an independent replication sample. We had 80% power to detect associations with a common SNP at an OR of 1.6 for psychotic symptoms and a mean difference of 1.8 years in age at onset. Age at onset and psychotic symptoms in BP may be influenced by many genes of smaller effect sizes or other variants not measured well by SNP arrays, such as rare alleles. © 2011 Wiley‐Liss, Inc.
Editor: Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Idioma: Inglês

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Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

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