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Molecular characterization of a family of ligands for eph‐related tyrosine kinase receptors

Beckmann, M.P. ; Cerretti, D.P. ; Baum, P. ; Vanden Bos, T. ; James, L. ; Farrah, T. ; Kozlosky, C. ; Hollingsworth, T. ; Shilling, H. ; Maraskovsky, E.

The EMBO journal, 1994-08, Vol.13 (16), p.3757-3762 [Periódico revisado por pares]

London: Nature Publishing Group

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Título:
Molecular characterization of a family of ligands for eph‐related tyrosine kinase receptors
Autor: Beckmann, M.P. ; Cerretti, D.P. ; Baum, P. ; Vanden Bos, T. ; James, L. ; Farrah, T. ; Kozlosky, C. ; Hollingsworth, T. ; Shilling, H. ; Maraskovsky, E.
Assuntos: Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; cDNA ; DNA-Binding Proteins ; elk gene ; Endothelium, Vascular - physiology ; eph gene ; Ephrin-A1 ; Ephrin-B1 ; ets-Domain Protein Elk-1 ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; Genes. Genome ; Humans ; man ; Molecular and cellular biology ; Molecular genetics ; Molecular Sequence Data ; Multigene Family - genetics ; nucleotide sequence ; Protein Binding ; protein-tyrosine kinase receptors ; Proteins - genetics ; Proteins - metabolism ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases - genetics ; Receptor Protein-Tyrosine Kinases - metabolism ; Receptor, EphA3 ; Recombinant Fusion Proteins - metabolism ; Retroviridae Proteins, Oncogenic - genetics ; Retroviridae Proteins, Oncogenic - metabolism ; RNA, Messenger - analysis ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Species Specificity ; Tissue Distribution ; Transcription Factors ; Tumor Necrosis Factor-alpha - pharmacology ; Umbilical Veins - physiology
É parte de: The EMBO journal, 1994-08, Vol.13 (16), p.3757-3762
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
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Descrição: A family of tyrosine kinase receptors related to the product of the eph gene has been described recently. One of these receptors, elk, has been shown to be expressed only in brain and testes. Using a direct expression cloning technique, a ligand for the elk receptor has been isolated by screening a human placenta cDNA library with a fusion protein containing the extracellular domain of the receptor. This isolated cDNA encodes a transmembrane protein. While the sequence of the ligand cDNA is unique, it is related to a previously described sequence known as B61. Northern blot analysis of human tissue mRNA showed that the elk ligand's mRNA is 3.5 kb long and is found in placenta, heart, lung, liver, skeletal muscle, kidney and pancreas. Southern blot analysis showed that the gene is highly conserved in a wide variety of species. Both elk ligand and B61 mRNAs are inducible by tumour necrosis factor in human umbilical vein endothelial cells. In addition, both proteins show promiscuity in binding to the elk and the related hek receptors. Since these two ligand sequences are similar, and since elk and hek are members of a larger family of eph‐related receptor molecules, we refer to these ligands as LERKs (ligands for eph‐related kinases).
Editor: London: Nature Publishing Group
Idioma: Inglês

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Molecular characterization of a family of ligands for eph‐related tyrosine kinase receptors

Beckmann, M.P. ; Cerretti, D.P. ; Baum, P. ; Vanden Bos, T. ; James, L. ; Farrah, T. ; Kozlosky, C. ; Hollingsworth, T. ; Shilling, H. ; Maraskovsky, E.

London: Nature Publishing Group

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