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Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci

Sanders, Stephan J. ; He, Xin ; Willsey, A. Jeremy ; Ercan-Sencicek, A. Gulhan ; Samocha, Kaitlin E. ; Cicek, A. Ercument ; Murtha, Michael T. ; Bal, Vanessa H. ; Bishop, Somer L. ; Dong, Shan ; Goldberg, Arthur P. ; Jinlu, Cai ; Keaney, John F. ; Klei, Lambertus ; Mandell, Jeffrey D. ; Moreno-De-Luca, Daniel ; Poultney, Christopher S. ; Robinson, Elise B. ; Smith, Louw ; Solli-Nowlan, Tor ; Su, Mack Y. ; Teran, Nicole A. ; Walker, Michael F. ; Werling, Donna M. ; Beaudet, Arthur L. ; Cantor, Rita M. ; Fombonne, Eric ; Geschwind, Daniel H. ; Grice, Dorothy E. ; Lord, Catherine ; Lowe, Jennifer K. ; Mane, Shrikant M. ; Martin, Donna M. ; Morrow, Eric M. ; Talkowski, Michael E. ; Sutcliffe, James S. ; Walsh, Christopher A. ; Yu, Timothy W. ; Ledbetter, David H. ; Martin, Christa Lese ; Cook, Edwin H. ; Buxbaum, Joseph D. ; Daly, Mark J. ; Devlin, Bernie ; Roeder, Kathryn ; State, Matthew W.

Neuron (Cambridge, Mass.), 2015-09, Vol.87 (6), p.1215-1233 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci
Autor: Sanders, Stephan J. ; He, Xin ; Willsey, A. Jeremy ; Ercan-Sencicek, A. Gulhan ; Samocha, Kaitlin E. ; Cicek, A. Ercument ; Murtha, Michael T. ; Bal, Vanessa H. ; Bishop, Somer L. ; Dong, Shan ; Goldberg, Arthur P. ; Jinlu, Cai ; Keaney, John F. ; Klei, Lambertus ; Mandell, Jeffrey D. ; Moreno-De-Luca, Daniel ; Poultney, Christopher S. ; Robinson, Elise B. ; Smith, Louw ; Solli-Nowlan, Tor ; Su, Mack Y. ; Teran, Nicole A. ; Walker, Michael F. ; Werling, Donna M. ; Beaudet, Arthur L. ; Cantor, Rita M. ; Fombonne, Eric ; Geschwind, Daniel H. ; Grice, Dorothy E. ; Lord, Catherine ; Lowe, Jennifer K. ; Mane, Shrikant M. ; Martin, Donna M. ; Morrow, Eric M. ; Talkowski, Michael E. ; Sutcliffe, James S. ; Walsh, Christopher A. ; Yu, Timothy W. ; Ledbetter, David H. ; Martin, Christa Lese ; Cook, Edwin H. ; Buxbaum, Joseph D. ; Daly, Mark J. ; Devlin, Bernie ; Roeder, Kathryn ; State, Matthew W.
Assuntos: Autism ; Autism Spectrum Disorder - diagnosis ; Autism Spectrum Disorder - genetics ; Female ; Females ; Genes ; Genetic Loci - genetics ; Genetic Variation - genetics ; Genomes ; Humans ; Male ; Mutation ; Protein Interaction Maps - genetics ; Siblings
É parte de: Neuron (Cambridge, Mass.), 2015-09, Vol.87 (6), p.1215-1233
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Analysis of de novo CNVs (dnCNVs) from the full Simons Simplex Collection (SSC) (N = 2,591 families) replicates prior findings of strong association with autism spectrum disorders (ASDs) and confirms six risk loci (1q21.1, 3q29, 7q11.23, 16p11.2, 15q11.2-13, and 22q11.2). The addition of published CNV data from the Autism Genome Project (AGP) and exome sequencing data from the SSC and the Autism Sequencing Consortium (ASC) shows that genes within small de novo deletions, but not within large dnCNVs, significantly overlap the high-effect risk genes identified by sequencing. Alternatively, large dnCNVs are found likely to contain multiple modest-effect risk genes. Overall, we find strong evidence that de novo mutations are associated with ASD apart from the risk for intellectual disability. Extending the transmission and de novo association test (TADA) to include small de novo deletions reveals 71 ASD risk loci, including 6 CNV regions (noted above) and 65 risk genes (FDR ≤ 0.1). •De novo copy number variants (dnCNV) are associated with Autism Spectrum Disorder/ASD•De novo mutations are associated with ASD in individuals with a high IQ•Small de novo deletions, but not large dnCNVs, contain one high-effect ASD risk gene•Identifies 6 ASD loci and 65 ASD genes, many of which target chromatin or the synapse Through analysis of de novo mutations in autism spectrum disorder (ASD), Sanders et al. find that small deletions, but not large deletions/duplications, contain one critical gene. Combining CNV and sequencing data, they identify 6 loci and 65 genes associated with ASD.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci

United States: Elsevier Inc

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