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Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

Patki, Gaurav ; Solanki, Naimesh ; Atrooz, Fatin ; Allam, Farida ; Salim, Samina

Brain research, 2013-11, Vol.1539, p.73-86 [Periódico revisado por pares]

Amsterdam: Elsevier B.V

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Título:
Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress
Autor: Patki, Gaurav ; Solanki, Naimesh ; Atrooz, Fatin ; Allam, Farida ; Salim, Samina
Assuntos: Adult and adolescent clinical studies ; amygdala ; animal models ; Animals ; Anxiety ; Anxiety - metabolism ; Biological and medical sciences ; body weight ; Brain - metabolism ; cortex ; Depression ; Depression - metabolism ; Disease Models, Animal ; glutathione-disulfide reductase ; hippocampus ; Inflammation ; interleukin-6 ; Learning and memory and social defeat ; Male ; Medical sciences ; memory ; Memory Disorders - metabolism ; Mood disorders ; Neurology ; Oxidative Stress ; Oxidative stress: depression ; protein kinases ; psychological stress ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Rats ; Rats, Long-Evans ; Rats, Sprague-Dawley ; Social Dominance ; Stress, Psychological - metabolism
É parte de: Brain research, 2013-11, Vol.1539, p.73-86
Notas: http://dx.doi.org/10.1016/j.brainres.2013.09.033
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Current address: Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Texas, USA. Tel: +1 713-743-1776; Fax: +1 713-743-1229
Descrição: Abstract In the present study, we have examined the behavioral and biochemical effect of induction of psychological stress using a modified version of the resident-intruder model for social stress (social defeat). At the end of the social defeat protocol, body weights, food and water intake were recorded, depression and anxiety-like behaviors as well as memory function was examined. Biochemical analysis including oxidative stress measurement, inflammatory markers and other molecular parameters, critical to behavioral effects were examined. We observed a significant decrease in the body weight in the socially defeated rats as compared to the controls. Furthermore, social defeat increased anxiety-like behavior and caused memory impairment in rats ( P <0.05). Socially defeated rats made significantly more errors in long term memory tests ( P <0.05) as compared to control rats. Furthermore, brain extracellular signal-regulated kinase-1/2 (ERK1/2), and an inflammatory marker, interleukin (IL)-6 were activated ( P <0.05), while the protein levels of glyoxalase (GLO)-1, glutathione reductase (GSR)-1, calcium/calmodulin-dependent protein kinase type (CAMK)-IV, cAMP-response-element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) were significantly less ( P <0.05) in the hippocampus, but not in the prefrontal cortex and amygdala of socially defeated rats, when compared to control rats. We suggest that social defeat stress alters ERK1/2, IL-6, GLO1, GSR1, CAMKIV, CREB, and BDNF levels in specific brain areas, leading to oxidative stress-induced anxiety–depression-like behaviors and as well as memory impairment in rats.
Editor: Amsterdam: Elsevier B.V
Idioma: Inglês

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Depression, anxiety-like behavior and memory impairment are associated with increased oxidative stress and inflammation in a rat model of social stress

Patki, Gaurav ; Solanki, Naimesh ; Atrooz, Fatin ; Allam, Farida ; Salim, Samina

Amsterdam: Elsevier B.V

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