Idioma:

Prolonged Activation of Brain CB2 Signaling Modulates Hypothalamic Microgliosis and Astrogliosis in High Fat Diet-Fed Mice

Rorato, Rodrigo ; Ferreira, Nathalia L ; Oliveira, Franciane P ; Fideles, Higor J ; Camilo, Tays A ; Antunes-Rodrigues, Jose ; Mecawi, Andre S ; Elias, Lucila L K

International journal of molecular sciences, 2022-05, Vol.23 (10), p.5527 [Periódico revisado por pares]

Switzerland: MDPI AG

Texto completo disponível

Citações Citado por

Enviar para

Título:
Prolonged Activation of Brain CB2 Signaling Modulates Hypothalamic Microgliosis and Astrogliosis in High Fat Diet-Fed Mice
Autor: Rorato, Rodrigo ; Ferreira, Nathalia L ; Oliveira, Franciane P ; Fideles, Higor J ; Camilo, Tays A ; Antunes-Rodrigues, Jose ; Mecawi, Andre S ; Elias, Lucila L K
Assuntos: Alzheimer's disease ; Animals ; Body Weight ; Body weight gain ; Brain ; Brain research ; Cannabinoid CB2 receptors ; CB2 signaling ; Cytokines ; Diet ; Diet, High-Fat - adverse effects ; Endocannabinoid system ; Energy ; Energy balance ; Food ; Gliosis ; Glucose ; Glucose tolerance ; glycaemia ; High fat diet ; Homeostasis ; hypothalamic gliosis ; Hypothalamus ; Hypothalamus (ventromedial) ; Immune response ; Immunological tolerance ; Inflammation ; Low fat diet ; Metabolism ; Mice ; Nervous system ; Nutrient deficiency ; Obesity ; Obesity - etiology ; Proteins ; Signaling ; Surgery
É parte de: International journal of molecular sciences, 2022-05, Vol.23 (10), p.5527
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These authors contributed equally to this work.
Descrição: Low-grade inflammation of the hypothalamus is associated with the disturbance of energy balance. The endocannabinoid system has been implicated in the development and maintenance of obesity as well as in the control of immune responses. The type 2 cannabinoid receptor (CB2) signaling has been associated with anti-inflammatory effects. Therefore, in high fat diet (HFD)-induced obese mice, we modulated CB2 signaling and investigated its effects on energy homeostasis and hypothalamic microgliosis/astrogliosis. We observed no effect on caloric intake and body weight gain in control diet-fed animals that received prolonged icv infusion of the CB2 receptor agonist HU308. Interestingly, we observed a decrease in glucose tolerance in HFD-fed animals treated with HU308. Prolonged icv infusion of HU308 increases astrogliosis in the ventromedial nucleus (VMH) of obese animals and reduced HFD-induced microgliosis in the hypothalamic arcuate (ARC) but not in the paraventricular (PVN) or VMH nuclei. These data indicate that central CB2 signaling modulates glucose homeostasis and glial reactivity in obesogenic conditions, irrespective of changes in body weight.
Editor: Switzerland: MDPI AG
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Prolonged Activation of Brain CB2 Signaling Modulates Hypothalamic Microgliosis and Astrogliosis in High Fat Diet-Fed Mice

Rorato, Rodrigo ; Ferreira, Nathalia L ; Oliveira, Franciane P ; Fideles, Higor J ; Camilo, Tays A ; Antunes-Rodrigues, Jose ; Mecawi, Andre S ; Elias, Lucila L K

Switzerland: MDPI AG

Buscando em bases de dados remotas. Favor aguardar.