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In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi

DE ARAUJO, J. S ; DA SILVA, C. F ; STEPHENS, C. E ; KUMAR, A ; BOYKIN, D. W ; SOEIRO, M. N. C ; BATISTA, D. G. J ; DA SILVA, P. B ; MEUSER, M. B ; AIUB, C. A. F ; DA SILVA, M. F. V ; ARAUJO-LIMA, C. F ; BANERJEE, M ; FARAHAT, A. A

Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4191-4195 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

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Título:
In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi
Autor: DE ARAUJO, J. S ; DA SILVA, C. F ; STEPHENS, C. E ; KUMAR, A ; BOYKIN, D. W ; SOEIRO, M. N. C ; BATISTA, D. G. J ; DA SILVA, P. B ; MEUSER, M. B ; AIUB, C. A. F ; DA SILVA, M. F. V ; ARAUJO-LIMA, C. F ; BANERJEE, M ; FARAHAT, A. A
Assuntos: Amidines ; Amidines - chemistry ; Amidines - therapeutic use ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Chagas Disease ; Chagas Disease - drug therapy ; Chagas Disease - mortality ; Chagas Disease - parasitology ; Experimental Therapeutics ; Male ; Medical sciences ; Mice ; Parasitemia ; Parasitemia - drug therapy ; Parasitemia - mortality ; Parasitemia - parasitology ; Parasitic Sensitivity Tests ; Pharmacology. Drug treatments ; Trypanocidal Agents ; Trypanocidal Agents - chemistry ; Trypanocidal Agents - therapeutic use ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects
É parte de: Antimicrobial agents and chemotherapy, 2014-07, Vol.58 (7), p.4191-4195
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J.S.D.A., C.F.D.S., and D.G.J.B. equally contributed to this work.
Descrição: Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.
Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

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In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi

DE ARAUJO, J. S ; DA SILVA, C. F ; STEPHENS, C. E ; KUMAR, A ; BOYKIN, D. W ; SOEIRO, M. N. C ; BATISTA, D. G. J ; DA SILVA, P. B ; MEUSER, M. B ; AIUB, C. A. F ; DA SILVA, M. F. V ; ARAUJO-LIMA, C. F ; BANERJEE, M ; FARAHAT, A. A

Washington, DC: American Society for Microbiology

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