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Molecularly imprinted polymers: synthetic receptors in bioanalysis

Tse Sum Bui, Bernadette ; Haupt, Karsten

Analytical and bioanalytical chemistry, 2010-11, Vol.398 (6), p.2481-2492 [Periódico revisado por pares]

Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag

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Título:
Molecularly imprinted polymers: synthetic receptors in bioanalysis
Autor: Tse Sum Bui, Bernadette ; Haupt, Karsten
Assuntos: Affinity ; Affinity separation ; Analytical Chemistry ; Antibodies ; Aqueous environments ; Binding Sites ; Bioanalysis ; Biochemistry ; Biosensing Techniques - instrumentation ; Biosensing Techniques - methods ; Characterization and Evaluation of Materials ; Chemical Sciences ; Chemistry ; Chemistry and Materials Science ; Enzymes ; Food Science ; Holes ; Imprinted polymers ; Laboratory Medicine ; Mathematical analysis ; Matrices ; Molecular imprinting ; Molecular Imprinting - methods ; Molecularly imprinted polymers ; Monitoring/Environmental Analysis ; Polymer industry ; Polymers ; Polymers - chemical synthesis ; Polymers - chemistry ; Receptors ; Review ; Solid Phase Extraction
É parte de: Analytical and bioanalytical chemistry, 2010-11, Vol.398 (6), p.2481-2492
Notas: http://dx.doi.org/10.1007/s00216-010-4158-x
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Descrição: Molecularly imprinted polymers (MIPs) are tailor-made synthetic materials possessing specific cavities designed for a target molecule. Since they recognise their target analyte with affinities and selectivities comparable to those of antibody-antigen, enzyme-substrate and ligand-receptor interactions, they are often referred to as synthetic receptors or plastic antibodies. In this review, we describe the great potential and recent developments of MIPs in affinity separations, with emphasis on their application to the solid-phase extraction (SPE) of analytes from complex matrices. Research efforts made in this field to obtain water-compatible polymers for their applicability in aqueous environments are described. We particularly discuss problems encountered in the use of MIPs in SPE and the attempts carried out to improve their efficiency. [graphic removed]
Editor: Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag
Idioma: Inglês

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Molecularly imprinted polymers: synthetic receptors in bioanalysis

Tse Sum Bui, Bernadette ; Haupt, Karsten

Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag

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